Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXL0GC)

• DTT Name: Enteropeptidase (TMPRSS15)
• Synonyms: Transmembrane protease serine 15; TMPRSS15; Serine protease 7; Enterokinase
• Gene Name: TMPRSS15
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Peptidase
• UniProt ID: ENTK_HUMAN
• TTD ID: T75772
• EC Number: EC 3.4.21.9
• Sequence:
  MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA
  TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII
  VVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV
  SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA
  THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN
  PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL
  NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP
  ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN
  AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST
  NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG
  PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN
  LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG
  LGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD
  ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI
  LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE
  NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE
  EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
• Function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Molecular Interaction Atlas (MIA) of This DTT

11 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8609715, A-1	DM5CULA	N. A.	N. A.	Patented	[2]
US8609715, A-26	DMY9SFE	N. A.	N. A.	Patented	[2]
US8609715, B-61	DMU26R7	N. A.	N. A.	Patented	[2]
US9024044, 1	DMPGY0M	N. A.	N. A.	Patented	[3]
US9024044, 2	DMWRXS8	N. A.	N. A.	Patented	[4]
US9024044, 3	DMKNDMB	N. A.	N. A.	Patented	[5]
US9024044, 4	DMANFK8	N. A.	N. A.	Patented	[4]
US9024044, 62	DMZKGOX	N. A.	N. A.	Patented	[5]
US9346821, A-20	DMSLBT3	N. A.	N. A.	Patented	[6]
US9346821, B-13	DMR6P8T	N. A.	N. A.	Patented	[6]
US9346821, B-42	DMQ1LGV	N. A.	N. A.	Patented	[6]

References

• [1] Enteropeptidase: a gene associated with a starvation human phenotype and a novel target for obesity treatment. PLoS One. 2012;7(11):e49612.
• [2] Heteroarylcarboxylic acid ester derivative. US8609715.
• [3] Heteroarylcarboxylic acid ester derivative. US9227949.
• [4] Heteroarylcarboxylic acid ester derivative. US9655879.
• [5] Heteroarylcarboxylic acid ester derivative. US9024044.
• [6] Heterocyclic carboxylic acid ester derivative. US9346821.