General Information of Drug Therapeutic Target (DTT) (ID: TTXSVQP)

DTT Name Homeobox protein Hox-A5 (HOXA5)
Synonyms Homeobox protein HoxA5; Homeobox protein Hox1C; Homeobox protein Hox-1C; HOX1C
Gene Name HOXA5
DTT Type
Literature-reported target
[1]
BioChemical Class
Antp homeobox
UniProt ID
HXA5_HUMAN
TTD ID
T08379
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG
SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKN
SLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWM
RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK
IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
Function
Binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

References

1 Knockdown of HOXA5 inhibits the tumorigenesis in esophageal squamous cell cancer. Biomed Pharmacother. 2017 Feb;86:149-154.