Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXWL6D)

DTT Name	Inositol-1(or4)-monophosphatase (IMPA2)
Synonyms	Myo-inositol-1-phosphate phosphohydrolase; Myo-inositol monophosphatase: IMP.18p; Lithium-sensitive myo-inositol monophosphatase A1; Inositol monophosphatase; IMPase; IMPA2; IMP
Gene Name	IMPA2
DTT Type	Literature-reported target	[1]
BioChemical Class	Phosphoric monoester hydrolase
UniProt ID	IMPA2_HUMAN
TTD ID	T76012
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.1.3.25
Sequence	MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHL VEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSI GFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDP ATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIR EAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK
Function	Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
KEGG Pathway	Inositol phosphate metabolism (hsa00562 ) Metabolic pathways (hsa01100 ) Phosphatidylinositol signaling system (hsa04070 )
Reactome Pathway	Synthesis of IP2, IP, and Ins in the cytosol (R-HSA-1855183 )
BioCyc Pathway	MetaCyc:HS06822-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Myo-Inositol-1-Phosphate	DM8LVQF	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.