General Information of Drug Therapeutic Target (DTT) (ID: TTXZAJ5)

DTT Name Galanin (GAL)
Synonyms Galanin peptides; Galanin messageassociated peptide; GMAP; GAL
Gene Name GAL
DTT Type
Literature-reported target
[1]
BioChemical Class
Galanin family
UniProt ID
GALA_HUMAN
TTD ID
T67877
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGL
TSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDI
ERS
Function Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
KEGG Pathway
Neuroactive ligand-receptor interaction (hsa04080 )
Reactome Pathway
G alpha (i) signalling events (R-HSA-418594 )
Peptide ligand-binding receptors (R-HSA-375276 )

References

1 Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J Mol Neurosci. 2002 Feb-Apr;18(1-2):151-65.