Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY078U)

DTT Name	IGF-binding protein 3 receptor (TMEM219)
Synonyms	Transmembrane protein 219; Insulin-like growth factor-binding protein 3 receptor; IGFBP-3R
Gene Name	TMEM219
DTT Type	Literature-reported target	[1]
UniProt ID	TM219_HUMAN
TTD ID	T02328
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSF LRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGS SAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVS VWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL
Function	Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
Reactome Pathway	TP53 Regulates Transcription of Death Receptors and Ligands (R-HSA-6803211 )

References

1	Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and P... Biochem Biophys Res Commun. 2016 Sep 16;478(2):964-9.