Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY3LAZ)

DTT Name	Opioid receptor sigma 2 (PGRMC1)
Synonyms	mPR; PGRMC; Membraneassociated progesterone receptor component 1; Membrane-associated progesterone receptor component 1; IZA; HPR6.6; Dap1
Gene Name	PGRMC1
DTT Type	Literature-reported target	[1]
BioChemical Class	GPCR rhodopsin
UniProt ID	PGRC1_HUMAN
TTD ID	T17814
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDD EPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRD ASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVY SDEEEPKDESARKND
Function	Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Component of a progesterone-binding protein complex.
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 )

References

1	PGRMC1 Is a Novel Potential Tumor Biomarker of Human Renal Cell Carcinoma Based on Quantitative Proteomic and Integrative Biological Assessments. PLoS One. 2017 Jan 20;12(1):e0170453.