Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYBS89)

DTT Name	Fibroleukin (FGL2)
Synonyms	PT49; Hfgl2; Fibrinogen-like protein 2; FGL2
Gene Name	FGL2
DTT Type	Literature-reported target	[1]
BioChemical Class	Fibrinogen
UniProt ID	FGL2_HUMAN
TTD ID	T85835
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVS LPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTG APGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANL TFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEV YCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMIL RIDLEDFNGVELYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPD KDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGG YKSSFKEAKMMIRPKHFKP
Function	May play a role in physiologic lymphocyte functions at mucosal sites.
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 )

References

1	Expression of human fibrinogen-like protein 2/fibroleukin in renal acute allograft rejection and its potential clinical implication. Zhonghua Yi Xue Za Zhi. 2004 Mar 17;84(6):474-7.