Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYED1Q)

• DTT Name: Hepatocellular carcinoma-associated protein (HCAP)
• Synonyms: YY1AP; YY1-associated protein 1; Hepatocellular carcinoma-associated protein 2; Hepatocellular carcinoma susceptibility protein; HCCA2; HCCA1
• Gene Name: YY1AP1
• DTT Type: Literature-reported target; [1]
• UniProt ID: YYAP1_HUMAN
• TTD ID: T62936
• Sequence:
  MEEEASRSAAATNPGSRLTRWPPPDKREGSAVDPGKRRSLAATPSSSLPCTLIALGLRHE
  KEANELMEDLFETFQDEMGFSNMEDDGPEEEERVAEPQANFNTPQALRFEELLANLLNEQ
  HQIAKELFEQLKMKKPSAKQQKEVEKVKPQCKEVHQTLILDPAQRKRLQQQMQQHVQLLT
  QIHLLATCNPNLNPEASSTRICLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLI
  EDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDK
  ILFTKAEDNKYLLTCKTARQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPH
  QWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDQGLEKDNSEL
  GSETRYPLLLPKGVVLKLKPVADRFPKKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPA
  QSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAMPPEARTSF
  PLSESQTLLSSAPVPKVMMPSPASSMFRKPYVRRRPSKRRGARAFRCIKPAPVIHPASVI
  FTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPIATLLVNPTSFPCPLNQPLVASSVS
  PLIVSGNSVNLPIPSTPEDKAHMNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPK
  VEHSPGPPPVDKQCQEGLSENSAYRWTVVKTEEGRQALEPLPQGIQESLNNSSPGDLEEV
  VKMEPEDATEEISGFL
• Function: Enhances transcription activation by YY1. Plays a role in cell cycle regulation. Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication.

References

• [1] Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma. Oncogene. 2002 Jul 25;21(32):4932-43.