Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYJRN5)

DTT Name N-acetylglucosaminyltransferase I (NAGAT1)
Synonyms N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; MGAT; GlcNAc-T I; GNT-I; GLCT1; GGNT1; Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Gene Name MGAT1
DTT Type
Patented-recorded target
 [1]
UniProt ID
MGAT1_HUMAN
TTD ID
T90751
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 2.4.1.101
Sequence
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
Function Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
KEGG Pathway
N-Glycan biosynthesis (hsa00510 )
Various types of N-glycan biosynthesis (hsa00513 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Maturation of spike protein (R-HSA-9683686 )
Maturation of spike protein (R-HSA-9694548 )
N-glycan trimming and elongation in the cis-Golgi (R-HSA-964739 )
BioCyc Pathway
MetaCyc:HS05528-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
9 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9586942, 16 DMERWUQ N. A. N. A. Patented [2]
US9586942, 2 DMZ745J N. A. N. A. Patented [2]
US9586942, 3* DMRXCYF N. A. N. A. Patented [2]
US9586945, 1 DM2RE91 N. A. N. A. Patented [3]
US9586945, 19a DMKZC4V N. A. N. A. Patented [3]
US9586945, 5 DM6A8XJ N. A. N. A. Patented [3]
US9656955, Example 351 DMXU8DI N. A. N. A. Patented [4]
US9656955, Example 540 DMC3Q9O N. A. N. A. Patented [4]
US9656955, Example 652 DMKS7D9 N. A. N. A. Patented [4]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Patented Agent(s)

References

1 N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition. FASEB J. 2019 Feb;33(2):2823-2835.
2 Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586942.
3 Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586945.
4 Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy. US9656955.