Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYVQ9C)

DTT Name	DNA fragmentation factor alpha (DFFA)
Synonyms	Inhibitor of caspase-3-activated Dnase; Inhibitor of CAD; ICAD; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF45; DFF1; DFF-45
Gene Name	DFFA
DTT Type	Literature-reported target	[1]
UniProt ID	DFFA_HUMAN
TTD ID	T38745
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVT LVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGA GLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLD QREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASH ILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQT QSLHSLRSISASKASPPGDLQNPKRARQDPT
Function	Inhibitor of the caspase-activated DNase (DFF40).
KEGG Pathway	Apoptosis (hsa04210 )
Reactome Pathway	Apoptosis induced DNA fragmentation (R-HSA-140342 )

References

1	Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. Cancer Res. 2002 Apr 1;62(7):2169-74.