General Information of Drug Therapeutic Target (DTT) (ID: TTZ1YIS)

DTT Name HUMAN dCTP pyrophosphatase 1
Synonyms XTP3-transactivated gene A protein ; RS21C6 ; Deoxycytidine-triphosphatase 1; dCTPase 1
Gene Name DCTPP1
UniProt ID
DCTP1_HUMAN
TTD ID
T01249
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.6.1.12
Sequence
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
Function Human protein dCTP pyrophosphatase 1 interacts with SARS-CoV-2 Orf9b protein with high significance, which indicates DCTPP1 as a potential therapeutic target.
KEGG Pathway
Pyrimidine metabolism (hsa00240 )
Metabolic pathways (hsa01100 )
Nucleotide metabolism (hsa01232 )
Reactome Pathway
Interconversion of nucleotide di- and triphosphates (R-HSA-499943 )

References

1 A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.