Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZA6B3)

• DTT Name: Citrate synthase (CS)
• Synonyms: Citrate synthase, mitochondrial; Citrate (Si)-synthase
• Gene Name: CS
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Acyltransferase
• UniProt ID: CISY_HUMAN
• TTD ID: T25690
• EC Number: EC 2.3.3.1
• Sequence:
  MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
  GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF
  WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN
  FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF
  TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL
  HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ
  REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
  TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG
• Function: extracellular exosome, mitochondrial matrix, mitochondrion, nucleus, citrate (Si)-synthase activity, RNA binding, carbohydrate metabolic process, tricarboxylic acid cycle.
• KEGG Pathway:
  Citrate cycle (TCA cycle) (hsa00020)
  Glyoxylate and dicarboxylate metabolism (hsa00630)
  Metabolic pathways (hsa01100)
  Carbon metabolism (hsa01200)
  2-Oxocarboxylic acid metabolism (hsa01210)
  Biosynthesis of amino acids (hsa01230)
• Reactome Pathway:
  Citric acid cycle (TCA cycle) (R-HSA-71403)
  Mitochondrial protein import (R-HSA-1268020)
• BioCyc Pathway: MetaCyc:ENSG00000062485-MON

References

• [1] STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth. Cell Rep. 2017 May 2;19(5):910-918.