Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZDAGB)

DTT Name	Lysophosphatidic acid receptor 6 (LPAR6)
Synonyms	RB intron encoded G-protein coupled receptor; Purinergic receptor 5; P2Y5; P2Y purinoceptor 5; P2RY5; Oleoyl-L-alpha-lysophosphatidic acid receptor; LPA-6; LPA receptor 6
Gene Name	LPAR6
DTT Type	Literature-reported target	[1]
UniProt ID	LPAR6_HUMAN
TTD ID	T13484
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLA MSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVY PFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTY LSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCF CFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQN SIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
Function	Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
KEGG Pathway	Phospholipase D signaling pathway (hsa04072 ) Neuroactive ligand-receptor interaction (hsa04080 ) PI3K-Akt signaling pathway (hsa04151 ) Pathways in cancer (hsa05200 )
Reactome Pathway	P2Y receptors (R-HSA-417957 ) G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LPA	DMI5XR1	Discovery agent	N.A.	Investigative	[1]
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References

1	G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34.