Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZHNQA)

DTT Name Insulin-like growth factor-binding protein 3 (IGFBP3)
Synonyms IGFBP-3; IGF-binding protein 3; IBP3; IBP-3
Gene Name IGFBP3
DTT Type
Clinical trial target
 [1]
BioChemical Class
Insulin-like growth factor binding
UniProt ID
IBP3_HUMAN
TTD ID
T33455
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
KEGG Pathway
p53 signaling pathway (hsa04115 )
Cellular senescence (hsa04218 )
Growth hormone synthesis, secretion and action (hsa04935 )
Transcriptional misregulation in cancer (hsa05202 )
Reactome Pathway
TP53 Regulates Transcription of Death Receptors and Ligands (R-HSA-6803211 )
Post-translational protein phosphorylation (R-HSA-8957275 )
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salvianolic acid B DMQVC3E Vascular dementia 6D81 Phase 2 [2]
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References

1 Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. Clin Cancer Res. 2008 Dec 15;14(24):8263-9.
2 Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3. J Mol Cell Cardiol. 2020 Feb;139:98-112.