General Information of Drug Therapeutic Target (DTT) (ID: TTZJ5U9)

DTT Name Thioredoxin (TXN)
Synonyms Trx; TRX1; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Gene Name TXN
DTT Type
Clinical trial target
[1]
UniProt ID
THIO_HUMAN
TTD ID
T85616
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
Function
Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
KEGG Pathway
NOD-like receptor signaling pathway (hsa04621 )
Parkinson disease (hsa05012 )
Salmonella infection (hsa05132 )
Fluid shear stress and atherosclerosis (hsa05418 )
Reactome Pathway
Detoxification of Reactive Oxygen Species (R-HSA-3299685 )
TP53 Regulates Metabolic Genes (R-HSA-5628897 )
The NLRP3 inflammasome (R-HSA-844456 )
Oxidative Stress Induced Senescence (R-HSA-2559580 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PX-12 DMLVHAJ Pancreatic cancer 2C10 Phase 2 [1]
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2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
Cacodylate Ion DMK4XLD Discovery agent N.A. Investigative [2]
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References

1 2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther. 2008 Jan;7(1):143-51.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.