Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZK4I3)

• DTT Name: Immunoglobulin gamma Fc receptor I (FCGR1)
• Synonyms: IgG Fc receptor I; FcRI; Fc-gamma RI; FCGR1A; CD64 antigen; CD64
• Gene Name: FCGR1A
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Immunoglobulin
• UniProt ID: FCGR1_HUMAN
• TTD ID: T10844
• Sequence:
  MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
  TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
  ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
  ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
  TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
  IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
  LQEGVHRKEPQGAT
• Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
• KEGG Pathway:
  Phagosome (hsa04145)
  Osteoclast differentiation (hsa04380)
  Neutrophil extracellular trap formation (hsa04613)
  Hematopoietic cell lineage (hsa04640)
  Fc gamma R-mediated phagocytosis (hsa04666)
  Leishmaniasis (hsa05140)
  Staphylococcus aureus infection (hsa05150)
  Tuberculosis (hsa05152)
  Transcriptional misregulation in cancer (hsa05202)
  Acute myeloid leukemia (hsa05221)
  Systemic lupus erythematosus (hsa05322)
• Reactome Pathway:
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933)
  FCGR activation (R-HSA-2029481)
  Regulation of actin dynamics for phagocytic cup formation (R-HSA-2029482)
  Role of phospholipids in phagocytosis (R-HSA-2029485)
  Interferon gamma signaling (R-HSA-877300)
  FCGR3A-mediated IL10 synthesis (R-HSA-9664323)
  Cross-presentation of soluble exogenous antigens (endosomes) (R-HSA-1236978)

References

• [1] Neutrophil Fc gamma RI as target for immunotherapy of invasive candidiasis. J Immunol. 2001 Jun 15;166(12):7019-22.