Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZN92A)

• DTT Name: DUSP5 messenger RNA (DUSP5 mRNA)
• Synonyms: VH3 (mRNA); Dual specificity protein phosphatase hVH3 (mRNA); Dual specificity protein phosphatase 5 (mRNA)
• Gene Name: DUSP5
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: DUS5_HUMAN
• TTD ID: T83398
• EC Number: EC 3.1.3.16
• Sequence:
  MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
  SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGP
  RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
  EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISS
  HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
  SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
  LAPVPTHSTVSELSRSPVATATSC
• Function: The highest relative activity is toward ERK1. Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues.
• KEGG Pathway: MAPK signaling pathway (hsa04010)
• Reactome Pathway:
  Negative regulation of MAPK pathway (R-HSA-5675221)
  RAF-independent MAPK1/3 activation (R-HSA-112409)

Molecular Interaction Atlas (MIA) of This DTT

8 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 133206	DMKY5LI	Discovery agent	N.A.	Investigative	[1]
ISIS 133207	DMR3KLF	Discovery agent	N.A.	Investigative	[1]
ISIS 133208	DMTSKQZ	Discovery agent	N.A.	Investigative	[1]
ISIS 133211	DMCGF2P	Discovery agent	N.A.	Investigative	[1]
ISIS 133242	DMP60XE	Discovery agent	N.A.	Investigative	[1]
ISIS 133243	DM2PIAZ	Discovery agent	N.A.	Investigative	[1]
ISIS 133244	DMTGFXI	Discovery agent	N.A.	Investigative	[1]
ISIS 133245	DMO09DU	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 6,867,039, Antisense modulation of dual specific phosphatase 5 expression.