Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZO36H)

• DTT Name: Glucose transporter type 12 (GLUT12)
• Synonyms: Solute carrier family 2, facilitated glucose transporter member 12; SLC2A12
• Gene Name: SLC2A12
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Major facilitator superfamily
• UniProt ID: GTR12_HUMAN
• TTD ID: T60156
• Sequence:
  MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI
  ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG
  SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL
  SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL
  RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY
  ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT
  MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM
  PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG
  PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLA
  SLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLE
  CNKLCGRGQSRQLSPET
• Function: Facilitative glucose transporter.
• Reactome Pathway: Cellular hexose transport (R-HSA-189200)

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Glucose transporter type 12 (SLC2A12) DTP Info
• Gene Name: SLC2A12

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[2]

References

• [1] GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer. 2018 Apr;25(4):453-469.
• [2] The human facilitative glucose transporter GLUT12: Expression and regulation in Caco-2 and 3T3-L1cells.