Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZS04O)

• DTT Name: Gamma-secretase subunit APH-1A/1B (APH-1)
• Synonyms: Anterior pharynx-defective 1
• Gene Name: APH1A-APH1B
• DTT Type: Patented-recorded target; [1]
• UniProt ID: APH1A_HUMAN-APH1B_HUMAN
• TTD ID: T05880
• Sequence:
  MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
  DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
  GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
  CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
  CLLCQDKNFLLYNQRSRMGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWL
  VSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLAS
  LSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFL
  TAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVS
  MGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED
• Function: The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Molecular Interaction Atlas (MIA) of This DTT

18 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28350212-Compound-1	DMSEIL0	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-12	DME72ZH	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-13	DMPWYL8	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-15	DMSFL5B	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-16	DMA1RP9	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-18	DMH8GC6	Alzheimer disease	8A20	Patented	[1]
PMID28350212-Compound-19	DMI4US6	Alzheimer disease	8A20	Patented	[1]
PMID28350212-Compound-20	DMM5G7S	Alzheimer disease	8A20	Patented	[1]
PMID28350212-Compound-21	DMFTGZC	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-22	DMKXZYC	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-23	DM3MVW1	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-24	DMPJH6L	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-25	DML2VUC	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-30	DMF1ZJ3	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-35	DMSKE2O	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-36	DM7ULWD	N. A.	N. A.	Patented	[1]
PMID28350212-Compound-7	DMUBSFV	Herpes simplex virus infection	1F00	Patented	[1]
Sulfonamide derivative 15	DM5CUSJ	N. A.	N. A.	Patented	[2]

References

• [1] Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866.
• [2] Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761.