Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZUJVE)

• DTT Name: Interleukin 18 receptor (IL18RAP)
• Synonyms: Interleukin18 receptor beta; Interleukin18 receptor accessory proteinlike; Interleukin18 receptor accessory protein; Interleukin1 receptor 7; Interleukin-18 receptor beta; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor accessory protein; Interleukin-1 receptor 7; IL1RAcPL; IL1R7; IL1R accessory proteinlike; IL18Rbeta; IL18RAcP; IL18 receptor accessory protein; IL-1RAcPL; IL-1R7; IL-1R-7; IL-1R accessory protein-like; IL-18Rbeta; IL-18RAcP; IL-18R-beta; IL-18 receptor accessory protein; CDw218b; CD218b; CD218 antigenlike family member B; CD218 antigen-like family member B; Accessory proteinlike; Accessory protein-like; AcPL
• Gene Name: IL18RAP
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Cytokine receptor
• UniProt ID: I18RA_HUMAN
• TTD ID: T71362
• Sequence:
  MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRN
  RLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNN
  SGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSC
  QSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQV
  RTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEV
  SVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVL
  LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF
  PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI
  LSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR
  GLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
• Function: May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.
• KEGG Pathway:
  Cytokine-cytokine receptor interaction (hsa04060)
  Viral protein interaction with cytokine and cytokine receptor (hsa04061)
  Inflammatory bowel disease (hsa05321)
• Reactome Pathway: Interleukin-18 signaling (R-HSA-9012546)

References

• [1] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J Exp Med. 2009 Jun 8;206(6):1395-408.