Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE2PJF5)

• DME Name: Acid cholesteryl ester hydrolase (LIPA) DME Info
• Gene Name: LIPA

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.51E-12	4.38E-01	5.62E-01
Alopecia	ED70	Skin from scalp	2.77E-07	2.68E-01	1.07E+00
Alzheimer's disease	8A20	Entorhinal cortex	6.03E-03	2.73E-01	4.45E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	5.46E-01	-4.00E-02	-5.15E-01
Aortic stenosis	BB70	Calcified aortic valve	6.00E-01	8.73E-02	8.06E-02
Apnea	7A40	Hyperplastic tonsil	5.83E-01	-1.53E-01	-2.28E-01
Arthropathy	FA00-FA5Z	Peripheral blood	8.68E-01	1.69E-02	4.99E-02
Asthma	CA23	Nasal and bronchial airway	5.42E-06	2.49E-01	2.99E-01
Atopic dermatitis	EA80	Skin	8.06E-01	1.11E-01	6.14E-01
Autism	6A02	Whole blood	2.72E-01	9.91E-02	2.27E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.30E-01	-4.83E-01	-1.40E+00
Autosomal dominant monocytopenia	4B04	Whole blood	4.33E-02	-8.74E-01	-1.40E+00
Bacterial infection of gingival	1C1H	Gingival tissue	1.55E-02	2.43E-01	6.49E-01
Batten disease	5C56.1	Whole blood	8.73E-01	-7.54E-02	-2.53E-01
Behcet's disease	4A62	Peripheral blood	4.34E-01	-1.60E-01	-4.74E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	3.63E-01	-2.82E-02	-7.70E-02
Bladder cancer	2C94	Bladder tissue	1.54E-05	-7.06E-01	-3.90E+00
Breast cancer	2C60-2C6Z	Breast tissue	3.26E-10	-2.94E-01	-4.89E-01
Cardioembolic stroke	8B11.20	Whole blood	1.37E-01	1.56E-02	6.70E-02
Cervical cancer	2C77	Cervical tissue	5.05E-02	2.37E-01	4.72E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	9.98E-01	-1.77E-01	-1.09E-01
Chronic hepatitis C	1E51.1	Whole blood	2.73E-01	-2.91E-01	-7.10E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	5.86E-02	2.16E-01	3.64E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	4.82E-02	1.51E-01	4.07E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	8.13E-02	-6.00E-01	-9.51E-01
Colon cancer	2B90	Colon tissue	4.46E-03	-2.93E-01	-3.37E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	7.07E-01	6.47E-01	7.92E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	8.53E-01	-2.62E-01	-4.02E-01
Endometriosis	GA10	Endometrium tissue	6.00E-01	7.91E-03	8.32E-03
Familial hypercholesterolemia	5C80.00	Peripheral blood	5.32E-01	5.02E-02	2.50E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.56E-06	1.30E+00	1.70E+00
Gastric cancer	2B72	Gastric tissue	4.58E-02	1.22E+00	2.21E+00
Glioblastopma	2A00.00	Nervous tissue	1.38E-02	1.53E-03	2.34E-03
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	3.45E-01	-5.88E-01	-9.26E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	8.70E-03	-6.41E-01	-9.23E-01
Head and neck cancer	2D42	Head and neck tissue	4.96E-03	3.70E-01	5.86E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	3.82E-01	3.73E-01	4.00E-01
Huntington's disease	8A01.10	Whole blood	7.25E-01	-4.88E-01	-9.09E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	1.31E-01	9.08E-01	1.09E+00
Immunodeficiency	4A00-4A20	Peripheral blood	7.43E-02	-2.14E-01	-9.71E-01
Influenza	1E30	Whole blood	2.52E-01	4.77E-01	6.07E-01
Interstitial cystitis	GC00.3	Bladder tissue	2.43E-03	5.57E-01	7.21E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.04E-03	1.58E+00	5.54E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.71E-01	1.18E-01	3.09E-01
Ischemic stroke	8B11	Peripheral blood	7.07E-01	8.20E-02	2.00E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	9.19E-02	-1.01E-02	-3.57E-02
Lateral sclerosis	8B60.4	Skin	8.71E-01	-1.18E-01	-2.01E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	1.59E-01	-6.99E-01	-6.29E-01
Liver cancer	2C12.0	Liver tissue	3.18E-02	-2.34E-01	-3.44E-01
Liver failure	DB99.7-DB99.8	Liver tissue	5.60E-05	1.78E+00	2.64E+00
Lung cancer	2C25	Lung tissue	2.19E-24	-5.06E-01	-8.65E-01
Lupus erythematosus	4A40	Whole blood	5.84E-01	1.19E-01	1.91E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	9.79E-01	-1.11E-02	-3.09E-02
Major depressive disorder	6A70-6A7Z	Whole blood	8.10E-01	-2.28E-02	-7.24E-02
Melanoma	2C30	Skin	1.72E-06	6.19E-01	1.57E+00
Multiple myeloma	2A83.1	Peripheral blood	5.08E-01	1.59E-01	2.55E-01
Multiple myeloma	2A83.1	Bone marrow	7.42E-01	-2.83E-01	-1.76E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.40E-01	-3.11E-01	-6.12E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	5.31E-02	2.44E-01	3.55E-01
Myelofibrosis	2A20.2	Whole blood	2.46E-01	-2.72E-01	-9.58E-01
Myocardial infarction	BA41-BA50	Peripheral blood	1.77E-01	-1.22E-01	-2.01E-01
Myopathy	8C70.6	Muscle tissue	4.00E-07	1.43E+00	4.57E+00
Neonatal sepsis	KA60	Whole blood	1.10E-01	2.33E-01	5.44E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.00E-06	-9.21E-01	-2.30E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.22E-01	5.53E-01	8.24E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	5.15E-01	-3.56E-02	-8.63E-02
Olive pollen allergy	CA08.00	Peripheral blood	9.00E-02	1.41E+00	2.07E+00
Oral cancer	2B6E	Oral tissue	4.44E-10	1.49E+00	1.85E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	5.65E-01	7.12E-01	5.71E-01
Osteoporosis	FB83.1	Bone marrow	1.78E-02	-1.15E+00	-3.68E+00
Ovarian cancer	2C73	Ovarian tissue	1.42E-03	5.71E-01	1.86E+00
Pancreatic cancer	2C10	Pancreas	7.28E-03	1.01E+00	1.11E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	1.73E-01	1.93E-01	3.90E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	8.91E-01	3.07E-02	1.19E-01
Pituitary cancer	2D12	Pituitary tissue	6.59E-04	6.35E-01	1.16E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	6.27E-03	7.13E-01	1.75E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.67E-01	-3.82E-02	-1.91E-01
Polycythemia vera	2A20.4	Whole blood	3.67E-01	-6.74E-03	-2.38E-02
Pompe disease	5C51.3	Biceps muscle	3.18E-03	9.98E-01	1.55E+00
Preterm birth	KA21.4Z	Myometrium	7.07E-01	-1.21E-01	-1.57E-01
Prostate cancer	2C82	Prostate	7.31E-01	6.10E-01	8.35E-01
Psoriasis	EA90	Skin	2.43E-13	4.21E-01	1.15E+00
Rectal cancer	2B92	Rectal colon tissue	1.23E-04	-1.06E+00	-3.52E+00
Renal cancer	2C90-2C91	Kidney	4.13E-06	1.96E+00	3.15E+00
Retinoblastoma	2D02.2	Uvea	9.75E-07	2.15E+00	8.36E+00
Rheumatoid arthritis	FA20	Synovial tissue	2.81E-01	4.39E-01	4.63E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.82E-01	-4.90E-02	-2.04E-01
Schizophrenia	6A20	Prefrontal cortex	3.72E-01	-4.58E-02	-5.19E-02
Schizophrenia	6A20	Superior temporal cortex	2.47E-01	-4.38E-02	-9.22E-02
Scleroderma	4A42.Z	Whole blood	1.24E-04	-3.29E-01	-2.11E+00
Seizure	8A60-8A6Z	Whole blood	3.44E-03	-6.13E-01	-1.73E+00
Sensitive skin	EK0Z	Skin	4.93E-01	9.31E-02	4.55E-01
Sepsis with septic shock	1G41	Whole blood	1.60E-19	-3.17E-01	-9.14E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.18E-01	-6.48E-01	-1.53E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.20E-03	8.82E-01	2.01E+00
Simpson golabi behmel syndrome	LD2C	Adipose tissue	6.22E-01	7.40E-02	2.75E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	9.22E-05	1.00E+00	5.94E+00
Skin cancer	2C30-2C3Z	Skin	2.01E-44	9.11E-01	2.07E+00
Thrombocythemia	3B63	Whole blood	7.18E-01	-8.08E-02	-2.85E-01
Thrombocytopenia	3B64	Whole blood	5.30E-01	-1.60E-01	-3.49E-01
Thyroid cancer	2D10	Thyroid	1.31E-08	5.56E-01	9.82E-01
Tibial muscular dystrophy	8C75	Muscle tissue	3.74E-08	1.27E+00	2.49E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	4.35E-01	7.55E-02	3.04E-01
Type 2 diabetes	5A11	Liver tissue	1.06E-01	1.93E-01	4.28E-01
Ureter cancer	2C92	Urothelium	5.67E-01	-2.64E-01	-4.43E-01
Uterine cancer	2C78	Endometrium tissue	6.99E-01	3.11E-02	4.04E-02
Vitiligo	ED63.0	Skin	9.50E-02	-1.09E-01	-6.52E-01