Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE6TFXV)

• DME Name: Tyrosine-protein phosphatase non-receptor 1 (PTP1B) DME Info
• Gene Name: PTPN1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	4.96E-02	3.77E-02	2.81E-01
Alopecia	ED70	Skin from scalp	8.00E-01	-9.75E-03	-5.00E-02
Alzheimer's disease	8A20	Entorhinal cortex	3.61E-01	-1.78E-02	-1.39E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.00E-01	1.72E-01	1.00E+00
Aortic stenosis	BB70	Calcified aortic valve	8.05E-01	1.12E-01	2.39E-01
Apnea	7A40	Hyperplastic tonsil	5.48E-01	4.36E-02	2.82E-01
Arthropathy	FA00-FA5Z	Peripheral blood	5.72E-01	8.64E-02	5.11E-01
Asthma	CA23	Nasal and bronchial airway	2.53E-06	-1.66E-01	-3.37E-01
Atopic dermatitis	EA80	Skin	7.28E-03	-6.29E-02	-6.95E-01
Autism	6A02	Whole blood	8.65E-01	-6.43E-03	-3.68E-02
Autoimmune uveitis	9A96	Peripheral monocyte	9.43E-02	-2.47E-01	-2.28E+00
Autosomal dominant monocytopenia	4B04	Whole blood	1.67E-01	2.56E-04	1.10E-03
Bacterial infection of gingival	1C1H	Gingival tissue	5.08E-06	9.17E-02	5.96E-01
Batten disease	5C56.1	Whole blood	2.43E-01	4.98E-02	6.08E-01
Behcet's disease	4A62	Peripheral blood	4.47E-01	-2.21E-02	-1.25E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	2.71E-01	-4.72E-02	-3.17E-01
Bladder cancer	2C94	Bladder tissue	4.33E-04	3.39E-01	2.42E+00
Breast cancer	2C60-2C6Z	Breast tissue	1.51E-03	2.25E-02	1.26E-01
Cardioembolic stroke	8B11.20	Whole blood	1.08E-02	-1.44E-01	-6.38E-01
Cervical cancer	2C77	Cervical tissue	6.07E-01	5.16E-02	2.51E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	3.80E-01	3.69E-02	1.93E-01
Chronic hepatitis C	1E51.1	Whole blood	2.23E-01	9.05E-02	5.98E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	5.24E-01	7.89E-02	3.33E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.36E-02	6.16E-02	5.08E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	9.74E-01	1.80E-02	1.83E-01
Colon cancer	2B90	Colon tissue	7.56E-08	-7.08E-02	-4.05E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	8.25E-01	7.38E-02	3.52E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.65E-01	-6.72E-02	-3.90E-01
Endometriosis	GA10	Endometrium tissue	5.98E-01	5.29E-02	3.79E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	7.34E-02	-9.54E-02	-9.52E-01
Familial hypercholesterolemia	5C80.00	Whole blood	5.88E-01	4.95E-03	3.79E-02
Gastric cancer	2B72	Gastric tissue	5.62E-01	-1.16E-01	-5.95E-01
Glioblastopma	2A00.00	Nervous tissue	3.54E-62	-2.15E-01	-1.13E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	8.85E-01	-2.20E-02	-9.57E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	7.74E-01	8.24E-02	3.74E-01
Head and neck cancer	2D42	Head and neck tissue	4.15E-01	-1.94E-02	-1.49E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.25E-01	-7.60E-02	-2.74E-01
Huntington's disease	8A01.10	Whole blood	7.45E-01	-4.60E-02	-2.96E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.92E-02	-3.83E-01	-9.70E-01
Immunodeficiency	4A00-4A20	Peripheral blood	7.37E-02	6.14E-02	7.50E-01
Influenza	1E30	Whole blood	9.39E-01	1.20E-01	5.55E-01
Interstitial cystitis	GC00.3	Bladder tissue	1.28E-01	1.14E-01	1.06E+00
Intracranial aneurysm	8B01.0	Intracranial artery	7.20E-01	-5.59E-02	-3.77E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	6.81E-01	-2.56E-02	-1.43E-01
Ischemic stroke	8B11	Peripheral blood	7.31E-01	5.86E-02	4.61E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.61E-02	6.19E-02	1.47E-01
Lateral sclerosis	8B60.4	Skin	6.47E-01	3.58E-02	4.33E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	6.08E-01	-6.46E-02	-2.76E-01
Liver cancer	2C12.0	Liver tissue	7.82E-08	-1.60E-01	-1.02E+00
Liver failure	DB99.7-DB99.8	Liver tissue	2.39E-01	-1.18E-01	-6.42E-01
Lung cancer	2C25	Lung tissue	1.50E-16	-1.72E-01	-7.02E-01
Lupus erythematosus	4A40	Whole blood	1.77E-01	-1.32E-03	-6.24E-03
Major depressive disorder	6A70-6A7Z	Hippocampus	5.44E-01	-1.80E-02	-1.32E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.44E-01	2.07E-02	1.11E-01
Melanoma	2C30	Skin	1.29E-01	2.44E-01	5.56E-01
Multiple myeloma	2A83.1	Peripheral blood	9.33E-01	3.92E-02	2.69E-01
Multiple myeloma	2A83.1	Bone marrow	2.20E-03	7.39E-02	9.74E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.36E-01	8.35E-02	2.74E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	8.11E-01	-2.76E-02	-2.73E-01
Myelofibrosis	2A20.2	Whole blood	1.84E-01	-1.19E-02	-1.56E-01
Myocardial infarction	BA41-BA50	Peripheral blood	9.96E-02	6.38E-02	1.47E-01
Myopathy	8C70.6	Muscle tissue	1.31E-02	-1.77E-01	-1.00E+00
Neonatal sepsis	KA60	Whole blood	3.11E-05	7.12E-02	4.92E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.57E-04	-5.09E-01	-2.10E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	7.09E-01	4.96E-02	2.35E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.39E-01	5.30E-02	3.85E-01
Olive pollen allergy	CA08.00	Peripheral blood	8.46E-01	4.18E-02	1.61E-01
Oral cancer	2B6E	Oral tissue	2.33E-02	-1.26E-01	-6.14E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.26E-01	-7.13E-02	-5.19E-01
Osteoporosis	FB83.1	Bone marrow	1.40E-01	2.65E-01	4.90E+00
Ovarian cancer	2C73	Ovarian tissue	1.28E-01	-1.45E-01	-7.76E-01
Pancreatic cancer	2C10	Pancreas	5.28E-04	-2.82E-01	-1.33E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	7.55E-01	5.90E-02	3.29E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.84E-02	5.39E-02	5.40E-01
Pituitary cancer	2D12	Pituitary tissue	1.47E-01	6.71E-02	4.02E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	9.22E-01	-7.62E-03	-4.14E-02
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	6.78E-02	-7.89E-02	-6.18E-01
Polycythemia vera	2A20.4	Whole blood	8.30E-02	4.60E-02	6.00E-01
Pompe disease	5C51.3	Biceps muscle	4.70E-01	-4.98E-02	-1.98E-01
Preterm birth	KA21.4Z	Myometrium	3.79E-01	-1.31E-02	-1.42E-01
Prostate cancer	2C82	Prostate	2.00E-01	4.73E-02	1.56E-01
Psoriasis	EA90	Skin	8.28E-02	-4.82E-02	-2.07E-01
Rectal cancer	2B92	Rectal colon tissue	5.47E-01	-4.55E-02	-2.72E-01
Renal cancer	2C90-2C91	Kidney	4.31E-03	-3.77E-01	-1.33E+00
Retinoblastoma	2D02.2	Uvea	6.66E-01	3.15E-02	3.37E-01
Rheumatoid arthritis	FA20	Synovial tissue	3.75E-02	-2.57E-01	-1.20E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	1.88E-01	1.71E-02	2.03E-01
Schizophrenia	6A20	Prefrontal cortex	6.82E-01	-4.19E-04	-3.41E-03
Schizophrenia	6A20	Superior temporal cortex	5.63E-01	4.77E-02	5.76E-01
Scleroderma	4A42.Z	Whole blood	2.76E-03	1.37E-01	1.07E+00
Seizure	8A60-8A6Z	Whole blood	4.36E-01	-4.41E-02	-3.12E-01
Sensitive skin	EK0Z	Skin	2.02E-01	9.44E-02	8.97E-01
Sepsis with septic shock	1G41	Whole blood	8.70E-08	1.34E-01	7.71E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.49E-01	-2.10E-02	-1.01E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.39E-01	1.57E-01	8.93E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	8.75E-01	-8.60E-04	-5.79E-03
Sjogren's syndrome	4A43.2	Salivary gland tissue	4.81E-01	-2.12E-02	-1.01E-01
Skin cancer	2C30-2C3Z	Skin	2.53E-02	-1.00E-02	-3.52E-02
Thrombocythemia	3B63	Whole blood	3.40E-01	-2.61E-02	-3.07E-01
Thrombocytopenia	3B64	Whole blood	6.04E-01	-1.66E-01	-3.93E-01
Thyroid cancer	2D10	Thyroid	4.04E-01	-2.77E-02	-1.38E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.72E-03	-1.74E-01	-8.86E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.51E-01	-3.82E-02	-3.35E-01
Type 2 diabetes	5A11	Liver tissue	9.44E-01	7.21E-03	7.84E-02
Ureter cancer	2C92	Urothelium	6.44E-02	-9.69E-02	-8.84E-01
Uterine cancer	2C78	Endometrium tissue	8.60E-03	-4.92E-02	-2.70E-01
Vitiligo	ED63.0	Skin	3.46E-02	2.02E-01	1.00E+00