Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEBIHM3)

• DME Name: Vitamin D 25-hydroxylase (CYP2R1) DME Info
• Gene Name: CYP2R1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	6.11E-08	9.96E-02	4.58E-01
Alopecia	ED70	Skin from scalp	1.38E-08	2.69E-01	1.19E+00
Alzheimer's disease	8A20	Entorhinal cortex	2.56E-01	-2.69E-02	-1.94E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	9.40E-01	1.07E-01	3.21E-01
Aortic stenosis	BB70	Calcified aortic valve	8.98E-01	-2.81E-02	-1.51E-01
Apnea	7A40	Hyperplastic tonsil	5.35E-01	4.06E-02	3.64E-01
Arthropathy	FA00-FA5Z	Peripheral blood	2.20E-01	-1.06E-01	-3.83E-01
Asthma	CA23	Nasal and bronchial airway	1.07E-02	1.78E-01	3.76E-01
Atopic dermatitis	EA80	Skin	9.36E-02	1.62E-01	6.00E-01
Autism	6A02	Whole blood	5.77E-01	-2.85E-02	-8.99E-02
Autoimmune uveitis	9A96	Peripheral monocyte	8.50E-01	-6.07E-02	-3.17E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.94E-01	-7.88E-02	-6.06E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.66E-08	-2.67E-01	-7.13E-01
Batten disease	5C56.1	Whole blood	3.61E-01	-2.02E-01	-5.26E-01
Behcet's disease	4A62	Peripheral blood	3.38E-01	-3.27E-01	-1.05E+00
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	4.19E-01	-1.46E-02	-7.94E-02
Bladder cancer	2C94	Bladder tissue	4.70E-02	7.19E-02	3.74E-01
Breast cancer	2C60-2C6Z	Breast tissue	9.57E-52	3.58E-01	1.25E+00
Cardioembolic stroke	8B11.20	Whole blood	8.54E-02	5.30E-02	1.69E-01
Cervical cancer	2C77	Cervical tissue	7.43E-03	-1.88E-01	-7.29E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	4.13E-01	-2.28E-01	-3.51E-01
Chronic hepatitis C	1E51.1	Whole blood	1.02E-01	-2.58E-01	-8.26E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.79E-02	-1.21E-01	-5.56E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	7.28E-01	-1.50E-03	-7.15E-03
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	9.75E-01	2.48E-02	2.23E-01
Colon cancer	2B90	Colon tissue	2.29E-10	1.40E-01	4.72E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	8.08E-01	1.37E-01	1.54E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.23E-01	8.24E-01	1.20E+00
Endometriosis	GA10	Endometrium tissue	2.94E-01	6.11E-02	2.85E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	1.93E-01	-2.59E-01	-9.07E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.19E-01	2.94E-01	9.91E-01
Gastric cancer	2B72	Gastric tissue	7.77E-02	2.67E-01	1.11E+00
Glioblastopma	2A00.00	Nervous tissue	1.19E-36	2.17E-01	7.10E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	7.99E-01	-1.01E-01	-2.11E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	3.33E-01	1.50E-01	3.62E-01
Head and neck cancer	2D42	Head and neck tissue	2.85E-01	2.61E-02	5.88E-02
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	9.12E-01	4.07E-02	1.98E-01
Huntington's disease	8A01.10	Whole blood	1.69E-01	9.08E-02	4.29E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.65E-01	-1.52E-01	-4.67E-01
Immunodeficiency	4A00-4A20	Peripheral blood	3.63E-05	-6.57E-01	-2.69E+00
Influenza	1E30	Whole blood	6.72E-01	-1.29E-01	-7.21E-01
Interstitial cystitis	GC00.3	Bladder tissue	3.94E-01	0.00E+00	0.00E+00
Intracranial aneurysm	8B01.0	Intracranial artery	4.95E-01	-6.62E-03	-1.94E-02
Irritable bowel syndrome	DD91.0	Rectal colon tissue	4.99E-01	7.28E-02	2.16E-01
Ischemic stroke	8B11	Peripheral blood	7.56E-02	-2.08E-01	-5.23E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	8.19E-02	1.79E-01	3.16E-01
Lateral sclerosis	8B60.4	Skin	9.12E-02	5.03E-02	7.51E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	1.08E-01	8.71E-02	6.34E-01
Liver cancer	2C12.0	Liver tissue	3.77E-15	3.15E-01	1.49E+00
Liver failure	DB99.7-DB99.8	Liver tissue	2.32E-01	5.92E-02	7.05E-01
Lung cancer	2C25	Lung tissue	1.24E-13	1.84E-01	5.83E-01
Lupus erythematosus	4A40	Whole blood	2.13E-01	-8.28E-02	-1.86E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	6.54E-01	-7.63E-03	-4.35E-02
Major depressive disorder	6A70-6A7Z	Whole blood	8.56E-01	4.39E-02	1.10E-01
Melanoma	2C30	Skin	1.59E-02	-4.33E-01	-4.45E-01
Multiple myeloma	2A83.1	Peripheral blood	2.62E-01	9.21E-02	3.59E-01
Multiple myeloma	2A83.1	Bone marrow	3.33E-05	3.59E-01	2.24E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.83E-01	-3.69E-02	-1.10E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.80E-05	8.94E-02	4.77E-01
Myelofibrosis	2A20.2	Whole blood	1.29E-06	-2.75E-01	-1.72E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.21E-01	-2.15E-01	-3.01E-01
Myopathy	8C70.6	Muscle tissue	9.68E-01	-9.62E-02	-2.98E-01
Neonatal sepsis	KA60	Whole blood	2.54E-05	-3.45E-01	-6.74E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.10E-03	2.45E-01	9.81E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	1.75E-01	5.70E-02	6.60E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	4.67E-01	2.03E-02	1.80E-01
Olive pollen allergy	CA08.00	Peripheral blood	9.41E-01	-1.08E-01	-3.74E-01
Oral cancer	2B6E	Oral tissue	4.32E-01	-7.54E-02	-2.34E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.66E-01	1.68E-01	6.45E-01
Osteoporosis	FB83.1	Bone marrow	3.70E-03	4.08E-01	2.91E+00
Ovarian cancer	2C73	Ovarian tissue	3.43E-01	-4.01E-02	-1.95E-01
Pancreatic cancer	2C10	Pancreas	7.63E-01	3.26E-02	6.99E-02
Parkinson's disease	8A00.0	Substantia nigra tissue	5.15E-01	8.14E-02	2.95E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.03E-01	-1.89E-01	-5.44E-01
Pituitary cancer	2D12	Pituitary tissue	1.13E-02	-5.20E-01	-1.75E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	4.78E-03	-2.89E-01	-1.04E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	3.13E-01	1.11E-01	7.95E-01
Polycythemia vera	2A20.4	Whole blood	6.00E-08	-9.57E-02	-7.53E-01
Pompe disease	5C51.3	Biceps muscle	6.19E-01	4.79E-03	2.37E-02
Preterm birth	KA21.4Z	Myometrium	8.87E-01	-9.60E-02	-7.62E-01
Prostate cancer	2C82	Prostate	9.91E-01	8.71E-02	1.83E-01
Psoriasis	EA90	Skin	4.51E-01	2.67E-02	6.45E-02
Rectal cancer	2B92	Rectal colon tissue	3.26E-01	-9.78E-02	-3.36E-01
Renal cancer	2C90-2C91	Kidney	1.80E-04	4.66E-01	2.03E+00
Retinoblastoma	2D02.2	Uvea	6.37E-01	-3.25E-02	-1.05E-01
Rheumatoid arthritis	FA20	Synovial tissue	1.68E-03	1.64E-01	1.78E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.40E-01	2.52E-02	1.43E-01
Schizophrenia	6A20	Prefrontal cortex	3.84E-01	1.25E-01	1.50E-01
Schizophrenia	6A20	Superior temporal cortex	3.01E-02	-7.07E-02	-5.13E-01
Scleroderma	4A42.Z	Whole blood	2.49E-02	-2.96E-01	-1.48E+00
Seizure	8A60-8A6Z	Whole blood	1.83E-01	1.28E-01	3.69E-01
Sensitive skin	EK0Z	Skin	5.21E-01	3.07E-01	1.27E+00
Sepsis with septic shock	1G41	Whole blood	1.29E-26	-3.86E-01	-1.05E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	5.00E-01	2.62E-02	6.75E-02
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.21E-01	1.04E-01	6.29E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.79E-01	2.38E-02	1.28E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.00E-01	-2.38E-01	-1.79E+00
Skin cancer	2C30-2C3Z	Skin	9.33E-13	-3.90E-01	-8.30E-01
Thrombocythemia	3B63	Whole blood	1.99E-07	-2.71E-01	-1.89E+00
Thrombocytopenia	3B64	Whole blood	3.88E-01	-9.76E-02	-2.02E-01
Thyroid cancer	2D10	Thyroid	6.66E-01	-1.53E-02	-5.00E-02
Tibial muscular dystrophy	8C75	Muscle tissue	4.84E-02	-1.61E-01	-8.11E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	7.76E-01	-1.13E-01	-6.37E-01
Type 2 diabetes	5A11	Liver tissue	3.78E-01	-8.19E-02	-3.74E-01
Ureter cancer	2C92	Urothelium	7.23E-01	8.45E-02	4.98E-01
Uterine cancer	2C78	Endometrium tissue	2.29E-01	7.44E-02	2.35E-01
Vitiligo	ED63.0	Skin	7.91E-02	2.74E-01	1.06E+00