Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEBS639)

• DME Name: Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info
• Gene Name: CYP27A1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.09E-04	9.38E-02	2.53E-01
Alopecia	ED70	Skin from scalp	9.66E-01	3.45E-02	8.53E-02
Alzheimer's disease	8A20	Entorhinal cortex	4.39E-04	2.42E-01	4.47E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.41E-01	6.36E-02	2.25E-01
Aortic stenosis	BB70	Calcified aortic valve	3.29E-01	-2.69E-01	-5.29E-01
Apnea	7A40	Hyperplastic tonsil	3.18E-01	1.51E-02	5.66E-02
Arthropathy	FA00-FA5Z	Peripheral blood	1.63E-01	3.06E-01	5.42E-01
Asthma	CA23	Nasal and bronchial airway	2.07E-04	-2.67E-01	-4.75E-01
Atopic dermatitis	EA80	Skin	1.58E-01	2.13E-01	8.49E-01
Autism	6A02	Whole blood	2.63E-01	1.63E-02	3.93E-02
Autoimmune uveitis	9A96	Peripheral monocyte	9.72E-02	4.45E-01	7.08E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.31E-01	1.07E-01	1.43E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.18E-01	5.57E-02	2.52E-01
Batten disease	5C56.1	Whole blood	6.09E-01	4.28E-01	6.54E-01
Behcet's disease	4A62	Peripheral blood	9.66E-01	-1.71E-01	-4.19E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.54E-01	2.10E-02	8.19E-02
Bladder cancer	2C94	Bladder tissue	6.46E-04	-9.96E-01	-2.75E+00
Breast cancer	2C60-2C6Z	Breast tissue	4.07E-05	-1.29E-01	-3.61E-01
Cardioembolic stroke	8B11.20	Whole blood	9.02E-02	1.18E-01	1.21E-01
Cervical cancer	2C77	Cervical tissue	1.42E-02	-1.44E-01	-6.13E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	3.90E-01	1.17E-01	1.98E-01
Chronic hepatitis C	1E51.1	Whole blood	8.05E-01	-1.69E-01	-6.33E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.66E-01	-4.53E-02	-1.02E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.92E-03	2.08E-01	4.43E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	5.28E-02	-8.13E-02	-3.16E-01
Colon cancer	2B90	Colon tissue	7.30E-35	-5.96E-01	-1.45E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	7.08E-01	-5.53E-02	-3.27E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.22E-01	-1.73E-02	-7.39E-02
Endometriosis	GA10	Endometrium tissue	9.01E-01	1.09E-01	1.86E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.55E-01	-1.10E-01	-4.66E-01
Familial hypercholesterolemia	5C80.00	Whole blood	4.37E-03	4.90E-01	1.02E+00
Gastric cancer	2B72	Gastric tissue	2.08E-01	5.27E-01	9.75E-01
Glioblastopma	2A00.00	Nervous tissue	5.44E-02	1.21E-01	1.84E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	1.07E-07	-9.79E-01	-1.51E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	9.26E-01	-1.74E-01	-1.90E-01
Head and neck cancer	2D42	Head and neck tissue	1.61E-06	-3.59E-01	-8.52E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	2.38E-01	3.07E-01	4.13E-01
Huntington's disease	8A01.10	Whole blood	6.02E-02	4.78E-01	8.78E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	6.24E-03	5.39E-01	1.66E+00
Immunodeficiency	4A00-4A20	Peripheral blood	8.35E-01	-2.84E-02	-2.62E-01
Influenza	1E30	Whole blood	2.57E-01	-6.00E-02	-2.97E-01
Interstitial cystitis	GC00.3	Bladder tissue	1.44E-04	-8.16E-01	-6.14E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.63E-03	8.38E-01	2.60E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	3.12E-02	-3.12E-01	-5.63E-01
Ischemic stroke	8B11	Peripheral blood	1.26E-01	-1.85E-01	-4.13E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	9.24E-02	-1.97E-01	-2.32E-01
Lateral sclerosis	8B60.4	Skin	8.84E-01	-2.81E-03	-7.23E-03
Lateral sclerosis	8B60.4	Cervical spinal cord	8.36E-02	2.85E-01	1.39E+00
Liver cancer	2C12.0	Liver tissue	2.50E-13	-4.93E-01	-1.02E+00
Liver failure	DB99.7-DB99.8	Liver tissue	8.06E-04	-1.79E+00	-3.71E+00
Lung cancer	2C25	Lung tissue	1.86E-65	-9.89E-01	-1.86E+00
Lupus erythematosus	4A40	Whole blood	3.27E-01	1.23E-01	2.23E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	5.51E-01	5.29E-02	2.30E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.21E-01	-3.80E-02	-6.05E-02
Melanoma	2C30	Skin	4.33E-01	2.22E-01	2.73E-01
Multiple myeloma	2A83.1	Peripheral blood	1.64E-01	1.19E-01	6.72E-01
Multiple myeloma	2A83.1	Bone marrow	3.55E-03	5.53E-01	1.59E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	4.51E-01	1.41E-01	3.76E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	5.14E-02	1.30E-01	5.30E-01
Myelofibrosis	2A20.2	Whole blood	1.60E-01	-1.16E-01	-5.78E-01
Myocardial infarction	BA41-BA50	Peripheral blood	2.37E-03	8.34E-01	6.45E-01
Myopathy	8C70.6	Muscle tissue	4.43E-01	-8.11E-02	-7.48E-01
Neonatal sepsis	KA60	Whole blood	9.66E-01	-1.36E-01	-2.47E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.15E-14	-1.38E+00	-7.77E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	7.88E-01	9.81E-02	1.89E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.77E-01	4.59E-03	1.83E-02
Olive pollen allergy	CA08.00	Peripheral blood	3.14E-01	5.90E-01	6.80E-01
Oral cancer	2B6E	Oral tissue	3.99E-10	-6.47E-01	-1.86E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	9.00E-01	1.85E-01	3.16E-01
Osteoporosis	FB83.1	Bone marrow	9.81E-01	8.80E-02	4.82E-01
Ovarian cancer	2C73	Ovarian tissue	9.24E-05	-6.81E-01	-2.30E+00
Pancreatic cancer	2C10	Pancreas	1.26E-01	2.51E-01	5.59E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	5.81E-03	3.82E-01	1.32E+00
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	6.43E-01	1.07E-02	3.27E-02
Pituitary cancer	2D12	Pituitary tissue	5.70E-01	3.94E-01	2.37E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.82E-03	4.01E-01	2.14E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	2.10E-02	9.44E-02	6.91E-01
Polycythemia vera	2A20.4	Whole blood	1.91E-01	7.77E-02	3.63E-01
Pompe disease	5C51.3	Biceps muscle	2.04E-01	3.23E-01	1.92E+00
Preterm birth	KA21.4Z	Myometrium	3.10E-02	-4.25E-01	-1.53E+00
Prostate cancer	2C82	Prostate	2.63E-08	-1.47E+00	-1.99E+00
Psoriasis	EA90	Skin	1.09E-34	-6.10E-01	-1.84E+00
Rectal cancer	2B92	Rectal colon tissue	6.07E-04	-8.19E-01	-2.91E+00
Renal cancer	2C90-2C91	Kidney	9.35E-01	-1.32E-01	-2.67E-01
Retinoblastoma	2D02.2	Uvea	2.42E-10	1.93E+00	1.02E+01
Rheumatoid arthritis	FA20	Synovial tissue	9.77E-06	5.91E-01	3.13E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	5.54E-02	-9.45E-02	-4.74E-01
Schizophrenia	6A20	Prefrontal cortex	1.87E-03	1.99E-01	4.12E-01
Schizophrenia	6A20	Superior temporal cortex	8.35E-02	-1.81E-01	-7.50E-01
Scleroderma	4A42.Z	Whole blood	1.16E-01	-2.45E-01	-7.83E-01
Seizure	8A60-8A6Z	Whole blood	8.02E-01	-7.01E-02	-1.28E-01
Sensitive skin	EK0Z	Skin	4.01E-01	9.70E-02	7.04E-01
Sepsis with septic shock	1G41	Whole blood	2.35E-02	-2.03E-01	-4.64E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.45E-01	1.94E-02	1.17E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.97E-02	-1.33E-01	-6.23E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.84E-01	-1.45E-01	-1.57E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.72E-01	-1.11E-01	-3.62E-01
Skin cancer	2C30-2C3Z	Skin	1.79E-09	4.80E-01	1.04E+00
Thrombocythemia	3B63	Whole blood	1.02E-01	2.40E-01	1.12E+00
Thrombocytopenia	3B64	Whole blood	4.43E-01	3.62E-01	7.56E-01
Thyroid cancer	2D10	Thyroid	8.78E-03	1.23E-01	3.23E-01
Tibial muscular dystrophy	8C75	Muscle tissue	3.07E-01	1.08E-01	4.31E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	6.17E-02	8.86E-01	2.34E+00
Type 2 diabetes	5A11	Liver tissue	2.59E-02	-2.64E-01	-1.34E+00
Ureter cancer	2C92	Urothelium	6.34E-01	-3.96E-02	-1.14E-01
Uterine cancer	2C78	Endometrium tissue	3.15E-14	-3.62E-01	-6.49E-01
Vitiligo	ED63.0	Skin	7.07E-02	-2.30E-01	-6.23E-01