Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEEBDFT)

• DME Name: Glutamate-cysteine ligase regulatory (GCLM) DME Info
• Gene Name: GCLM

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.11E-32	-1.53E+00	-1.60E+00
Alopecia	ED70	Skin from scalp	3.55E-05	-3.14E-01	-9.91E-01
Alzheimer's disease	8A20	Entorhinal cortex	6.78E-01	-1.29E-03	-4.18E-03
Ankylosing spondylitis	FA92.0	Pheripheral blood	3.79E-01	2.00E-02	4.05E-02
Aortic stenosis	BB70	Calcified aortic valve	5.80E-01	4.55E-01	8.42E-01
Apnea	7A40	Hyperplastic tonsil	4.70E-01	-2.04E-01	-2.10E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.10E-01	-3.39E-01	-9.14E-01
Asthma	CA23	Nasal and bronchial airway	1.08E-04	2.86E-01	2.97E-01
Atopic dermatitis	EA80	Skin	2.50E-03	4.30E-01	1.18E+00
Autism	6A02	Whole blood	2.53E-02	8.05E-02	2.05E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.72E-01	3.47E-01	8.49E-01
Autosomal dominant monocytopenia	4B04	Whole blood	8.42E-02	9.20E-01	1.02E+00
Bacterial infection of gingival	1C1H	Gingival tissue	6.22E-01	3.80E-02	4.91E-02
Batten disease	5C56.1	Whole blood	2.34E-01	-1.29E-02	-4.15E-02
Behcet's disease	4A62	Peripheral blood	7.28E-01	1.53E-02	3.46E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.89E-01	2.95E-02	8.82E-02
Bladder cancer	2C94	Bladder tissue	7.32E-01	-1.17E-02	-1.91E-02
Breast cancer	2C60-2C6Z	Breast tissue	1.52E-04	-1.85E-01	-2.51E-01
Cardioembolic stroke	8B11.20	Whole blood	2.81E-01	6.88E-02	2.55E-01
Cervical cancer	2C77	Cervical tissue	7.92E-03	2.66E-01	3.11E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	5.07E-01	1.79E-01	2.82E-01
Chronic hepatitis C	1E51.1	Whole blood	2.17E-01	-1.20E-01	-2.92E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.63E-01	-9.27E-02	-1.37E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	4.14E-03	3.76E-01	5.55E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	3.46E-01	-7.56E-01	-8.34E-01
Colon cancer	2B90	Colon tissue	1.53E-07	2.53E-01	4.45E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	3.84E-01	4.15E-01	8.04E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	5.27E-01	5.15E-01	7.24E-01
Endometriosis	GA10	Endometrium tissue	6.99E-02	3.46E-01	4.28E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	9.40E-01	1.99E-01	6.02E-01
Familial hypercholesterolemia	5C80.00	Whole blood	7.86E-01	2.68E-02	5.78E-02
Gastric cancer	2B72	Gastric tissue	1.95E-01	6.52E-01	5.38E-01
Glioblastopma	2A00.00	Nervous tissue	2.75E-25	5.18E-01	7.87E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	5.40E-01	-4.69E-01	-6.69E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	9.23E-01	-2.01E-02	-3.12E-02
Head and neck cancer	2D42	Head and neck tissue	1.37E-01	-3.73E-01	-3.80E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	9.36E-01	2.12E-01	3.09E-01
Huntington's disease	8A01.10	Whole blood	3.42E-01	6.10E-02	1.52E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	1.30E-01	-6.91E-01	-6.64E-01
Immunodeficiency	4A00-4A20	Peripheral blood	1.08E-01	-2.06E-01	-9.87E-01
Influenza	1E30	Whole blood	7.31E-01	-1.44E-01	-4.64E-01
Interstitial cystitis	GC00.3	Bladder tissue	7.49E-01	1.82E-02	4.35E-02
Intracranial aneurysm	8B01.0	Intracranial artery	2.33E-01	3.64E-01	3.50E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	4.42E-01	9.85E-02	2.47E-01
Ischemic stroke	8B11	Peripheral blood	5.42E-01	-7.60E-02	-1.90E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.87E-01	7.53E-02	2.02E-01
Lateral sclerosis	8B60.4	Skin	3.38E-01	-1.64E-01	-3.60E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.32E-01	-3.00E-01	-2.72E-01
Liver cancer	2C12.0	Liver tissue	3.71E-01	-2.09E-01	-2.22E-01
Liver failure	DB99.7-DB99.8	Liver tissue	3.24E-01	-2.57E-01	-4.59E-01
Lung cancer	2C25	Lung tissue	1.71E-21	3.54E-01	6.80E-01
Lupus erythematosus	4A40	Whole blood	9.55E-02	1.25E-01	1.84E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	2.91E-01	8.07E-02	2.39E-01
Major depressive disorder	6A70-6A7Z	Whole blood	4.69E-01	-3.70E-02	-7.93E-02
Melanoma	2C30	Skin	1.14E-02	-9.99E-01	-9.12E-01
Multiple myeloma	2A83.1	Peripheral blood	6.96E-01	-5.44E-02	-1.37E-01
Multiple myeloma	2A83.1	Bone marrow	1.72E-01	4.46E-02	1.30E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	4.35E-01	-1.45E-01	-2.99E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.00E-04	2.11E-01	3.98E-01
Myelofibrosis	2A20.2	Whole blood	3.45E-03	1.65E+00	3.60E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.63E-03	-3.55E-01	-6.04E-01
Myopathy	8C70.6	Muscle tissue	1.25E-01	-2.13E-01	-3.04E-01
Neonatal sepsis	KA60	Whole blood	1.59E-35	1.24E+00	2.91E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	4.02E-05	1.02E+00	1.98E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.08E-01	7.31E-01	8.18E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	7.73E-01	-4.37E-01	-4.55E-01
Olive pollen allergy	CA08.00	Peripheral blood	3.38E-01	-4.70E-01	-1.10E+00
Oral cancer	2B6E	Oral tissue	1.20E-03	7.91E-01	7.07E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	9.00E-01	-2.17E-01	-1.07E-01
Osteoporosis	FB83.1	Bone marrow	4.47E-01	-6.34E-01	-8.07E-01
Ovarian cancer	2C73	Ovarian tissue	1.55E-01	6.08E-01	4.83E-01
Pancreatic cancer	2C10	Pancreas	2.86E-01	5.04E-01	5.93E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	2.94E-01	-1.69E-01	-2.17E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.73E-02	1.87E-01	3.49E-01
Pituitary cancer	2D12	Pituitary tissue	4.76E-02	3.98E-01	7.67E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.12E-01	1.00E-01	1.85E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	7.36E-01	8.27E-02	1.53E-01
Polycythemia vera	2A20.4	Whole blood	7.84E-09	6.76E-01	1.52E+00
Pompe disease	5C51.3	Biceps muscle	9.84E-01	-1.04E-02	-3.82E-02
Preterm birth	KA21.4Z	Myometrium	2.48E-01	2.53E-01	7.17E-01
Prostate cancer	2C82	Prostate	3.45E-01	4.10E-01	3.95E-01
Psoriasis	EA90	Skin	6.34E-01	-4.40E-03	-6.20E-03
Rectal cancer	2B92	Rectal colon tissue	8.46E-02	7.11E-01	1.03E+00
Renal cancer	2C90-2C91	Kidney	8.70E-04	1.90E+00	1.89E+00
Retinoblastoma	2D02.2	Uvea	3.85E-04	1.01E+00	3.40E+00
Rheumatoid arthritis	FA20	Synovial tissue	8.92E-01	-3.44E-01	-3.02E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	8.77E-01	9.90E-02	2.33E-01
Schizophrenia	6A20	Prefrontal cortex	6.94E-01	-1.02E-01	-1.53E-01
Schizophrenia	6A20	Superior temporal cortex	8.08E-01	5.08E-02	2.15E-01
Scleroderma	4A42.Z	Whole blood	1.18E-02	-8.52E-01	-1.57E+00
Seizure	8A60-8A6Z	Whole blood	3.79E-02	3.11E-01	6.41E-01
Sensitive skin	EK0Z	Skin	4.39E-01	-3.29E-01	-1.32E+00
Sepsis with septic shock	1G41	Whole blood	1.67E-116	1.54E+00	3.39E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.97E-02	5.38E-01	1.69E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.52E-02	6.62E-01	7.96E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	2.52E-01	8.93E-01	1.68E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	3.11E-01	7.35E-01	1.31E+00
Skin cancer	2C30-2C3Z	Skin	3.46E-01	-1.03E-02	-1.40E-02
Thrombocythemia	3B63	Whole blood	6.45E-07	7.47E-01	1.63E+00
Thrombocytopenia	3B64	Whole blood	5.60E-01	-2.26E-01	-2.06E-01
Thyroid cancer	2D10	Thyroid	4.41E-04	-2.89E-01	-4.97E-01
Tibial muscular dystrophy	8C75	Muscle tissue	4.25E-01	2.06E-01	4.55E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.01E-02	-4.89E-01	-1.81E+00
Type 2 diabetes	5A11	Liver tissue	4.36E-01	3.52E-01	6.46E-01
Ureter cancer	2C92	Urothelium	8.91E-02	2.43E-02	1.67E-01
Uterine cancer	2C78	Endometrium tissue	4.69E-35	1.19E+00	1.54E+00
Vitiligo	ED63.0	Skin	5.27E-01	-3.07E-01	-8.08E-01