Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEQ6NC9)

• DME Name: S-adenosylmethionine synthase 1 (MAT1A) DME Info
• Gene Name: MAT1A

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	4.93E-01	-3.20E-02	-1.16E-01
Alopecia	ED70	Skin from scalp	9.13E-01	-3.87E-02	-1.02E-01
Alzheimer's disease	8A20	Entorhinal cortex	8.94E-01	-6.85E-03	-3.83E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	9.42E-01	-1.57E-02	-1.02E-01
Aortic stenosis	BB70	Calcified aortic valve	4.45E-01	2.01E-01	5.07E-01
Apnea	7A40	Hyperplastic tonsil	3.44E-01	-4.12E-01	-8.82E-01
Arthropathy	FA00-FA5Z	Peripheral blood	8.98E-01	1.52E-02	1.10E-01
Asthma	CA23	Nasal and bronchial airway	3.77E-03	-9.95E-02	-1.34E-01
Atopic dermatitis	EA80	Skin	1.23E-01	-2.30E-01	-9.75E-01
Autism	6A02	Whole blood	1.46E-01	-1.14E-01	-3.26E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.46E-01	-8.92E-02	-4.90E-01
Autosomal dominant monocytopenia	4B04	Whole blood	5.86E-01	-1.37E-02	-7.81E-02
Bacterial infection of gingival	1C1H	Gingival tissue	3.08E-01	9.06E-03	1.89E-02
Batten disease	5C56.1	Whole blood	6.12E-01	1.04E-01	8.12E-01
Behcet's disease	4A62	Peripheral blood	4.10E-02	2.01E-01	9.67E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	4.79E-01	-1.09E-01	-5.33E-01
Bladder cancer	2C94	Bladder tissue	7.53E-10	8.02E-01	8.37E+00
Breast cancer	2C60-2C6Z	Breast tissue	1.70E-05	-1.32E-01	-2.73E-01
Cardioembolic stroke	8B11.20	Whole blood	6.88E-01	1.75E-02	9.69E-02
Cervical cancer	2C77	Cervical tissue	2.01E-01	-1.00E-01	-3.96E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	5.99E-01	-1.00E-01	-3.76E-01
Chronic hepatitis C	1E51.1	Whole blood	2.66E-01	4.96E-02	2.46E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	1.90E-02	6.15E-02	2.06E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	5.39E-03	1.98E-01	6.03E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.87E-01	-1.10E-01	-3.99E-01
Colon cancer	2B90	Colon tissue	1.59E-17	1.93E-01	6.47E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	5.42E-01	-4.44E-03	-2.40E-02
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.95E-01	-6.62E-02	-2.91E-01
Endometriosis	GA10	Endometrium tissue	3.38E-02	3.28E-01	7.95E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.00E-01	1.37E-01	8.48E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.78E-06	-5.92E-01	-1.53E+00
Gastric cancer	2B72	Gastric tissue	2.25E-01	-2.25E-01	-6.88E-01
Glioblastopma	2A00.00	Nervous tissue	3.99E-06	-1.80E-01	-4.56E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.36E-05	1.11E-01	2.23E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.93E-08	-8.75E-01	-3.63E+00
Head and neck cancer	2D42	Head and neck tissue	4.04E-11	-3.59E-01	-8.31E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	2.74E-01	-2.04E-02	-6.75E-02
Huntington's disease	8A01.10	Whole blood	1.84E-01	1.24E-02	1.22E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	5.18E-01	1.22E-01	4.16E-01
Immunodeficiency	4A00-4A20	Peripheral blood	3.82E-01	7.11E-02	9.32E-01
Influenza	1E30	Whole blood	8.86E-04	5.23E-01	4.84E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.56E-01	2.01E-01	9.89E-01
Intracranial aneurysm	8B01.0	Intracranial artery	6.21E-01	2.31E-02	1.04E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	5.17E-01	1.82E-02	4.55E-02
Ischemic stroke	8B11	Peripheral blood	5.94E-02	6.02E-02	3.75E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.41E-02	1.00E-01	3.57E-01
Lateral sclerosis	8B60.4	Skin	4.76E-01	-8.20E-02	-3.91E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	9.28E-01	1.31E-01	4.11E-01
Liver cancer	2C12.0	Liver tissue	1.21E-41	-1.67E+00	-3.60E+00
Liver failure	DB99.7-DB99.8	Liver tissue	3.79E-03	-3.84E+00	-1.01E+01
Lung cancer	2C25	Lung tissue	5.44E-01	-1.17E-04	-3.82E-04
Lupus erythematosus	4A40	Whole blood	1.49E-01	-1.24E-01	-1.87E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.86E-01	-1.51E-02	-7.84E-02
Major depressive disorder	6A70-6A7Z	Whole blood	5.23E-02	4.89E-02	2.15E-01
Melanoma	2C30	Skin	3.32E-01	5.79E-01	6.64E-01
Multiple myeloma	2A83.1	Peripheral blood	7.95E-01	5.38E-02	2.61E-01
Multiple myeloma	2A83.1	Bone marrow	3.34E-05	-7.26E-01	-3.47E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.33E-01	1.94E-01	6.76E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	9.03E-01	-5.99E-03	-2.55E-02
Myelofibrosis	2A20.2	Whole blood	1.66E-01	6.87E-02	5.77E-01
Myocardial infarction	BA41-BA50	Peripheral blood	3.23E-02	4.65E-01	7.45E-01
Myopathy	8C70.6	Muscle tissue	2.66E-01	-6.79E-02	-3.69E-01
Neonatal sepsis	KA60	Whole blood	1.30E-01	-2.68E-02	-7.32E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.48E-04	-1.12E+00	-2.05E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	5.75E-01	-3.45E-02	-1.68E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	4.17E-01	8.70E-02	4.06E-01
Olive pollen allergy	CA08.00	Peripheral blood	8.26E-02	3.42E-01	1.48E+00
Oral cancer	2B6E	Oral tissue	1.36E-04	-4.99E-01	-9.43E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.15E-01	-1.48E-01	-1.51E+00
Osteoporosis	FB83.1	Bone marrow	3.97E-02	4.14E-01	6.52E+00
Ovarian cancer	2C73	Ovarian tissue	4.53E-01	-2.54E-01	-5.54E-01
Pancreatic cancer	2C10	Pancreas	7.23E-03	-1.03E+00	-1.24E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	6.47E-01	3.35E-02	1.07E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	4.70E-01	5.96E-02	4.18E-01
Pituitary cancer	2D12	Pituitary tissue	2.12E-01	-5.48E-02	-1.45E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	8.14E-01	-1.66E-02	-6.22E-02
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.06E-01	1.14E-01	7.03E-01
Polycythemia vera	2A20.4	Whole blood	2.88E-04	1.47E-01	1.05E+00
Pompe disease	5C51.3	Biceps muscle	2.37E-01	-1.63E-02	-8.81E-02
Preterm birth	KA21.4Z	Myometrium	8.42E-01	-6.52E-02	-3.32E-01
Prostate cancer	2C82	Prostate	3.94E-04	-1.09E+00	-1.55E+00
Psoriasis	EA90	Skin	3.16E-09	-1.44E-01	-3.24E-01
Rectal cancer	2B92	Rectal colon tissue	3.75E-02	1.15E-01	8.42E-01
Renal cancer	2C90-2C91	Kidney	2.60E-03	-6.16E-01	-1.62E+00
Retinoblastoma	2D02.2	Uvea	1.60E-01	1.63E-01	9.38E-01
Rheumatoid arthritis	FA20	Synovial tissue	6.80E-01	2.17E-01	1.07E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.54E-01	-3.71E-03	-2.25E-02
Schizophrenia	6A20	Prefrontal cortex	5.63E-01	3.18E-02	7.60E-02
Schizophrenia	6A20	Superior temporal cortex	2.01E-01	-6.25E-02	-5.65E-01
Scleroderma	4A42.Z	Whole blood	5.30E-02	-1.78E-01	-8.61E-01
Seizure	8A60-8A6Z	Whole blood	6.65E-01	-1.72E-01	-5.85E-01
Sensitive skin	EK0Z	Skin	9.76E-02	-2.44E-02	-4.80E-01
Sepsis with septic shock	1G41	Whole blood	1.74E-01	6.82E-02	1.68E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	9.14E-02	5.53E-01	8.39E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.96E-02	1.19E-01	5.81E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	6.03E-01	-2.94E-02	-2.79E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	4.81E-01	-1.61E-01	-6.76E-01
Skin cancer	2C30-2C3Z	Skin	8.32E-04	-2.52E-01	-4.79E-01
Thrombocythemia	3B63	Whole blood	2.15E-03	1.16E-01	9.24E-01
Thrombocytopenia	3B64	Whole blood	2.72E-01	4.84E-02	2.35E-01
Thyroid cancer	2D10	Thyroid	3.56E-03	4.34E-02	1.60E-01
Tibial muscular dystrophy	8C75	Muscle tissue	6.44E-01	-2.75E-02	-1.49E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.81E-01	1.82E-02	1.08E-01
Type 2 diabetes	5A11	Liver tissue	1.90E-01	-1.87E-01	-6.44E-01
Ureter cancer	2C92	Urothelium	9.77E-01	-3.20E-02	-9.61E-02
Uterine cancer	2C78	Endometrium tissue	2.35E-01	1.44E-01	3.65E-01
Vitiligo	ED63.0	Skin	8.55E-01	-1.45E-01	-2.85E-01