Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DETH24K)

• DME Name: Red cell/liver pyruvate kinase (PKLR) DME Info
• Gene Name: PKLR

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.63E-37	-1.31E+00	-1.87E+00
Alopecia	ED70	Skin from scalp	7.28E-02	2.28E-01	3.20E-01
Alzheimer's disease	8A20	Entorhinal cortex	7.39E-03	-4.35E-02	-2.47E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	3.82E-01	-8.82E-02	-7.14E-01
Aortic stenosis	BB70	Calcified aortic valve	7.34E-01	-2.84E-01	-5.33E-01
Apnea	7A40	Hyperplastic tonsil	3.19E-01	-3.50E-01	-1.01E+00
Arthropathy	FA00-FA5Z	Peripheral blood	9.55E-01	-5.71E-02	-3.90E-01
Asthma	CA23	Nasal and bronchial airway	4.03E-02	-1.13E-01	-3.15E-01
Atopic dermatitis	EA80	Skin	6.40E-01	-8.45E-02	-4.75E-01
Autism	6A02	Whole blood	7.15E-01	2.48E-02	1.07E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.35E-03	-1.75E-01	-8.86E-01
Autosomal dominant monocytopenia	4B04	Whole blood	7.06E-01	-9.23E-03	-7.22E-02
Bacterial infection of gingival	1C1H	Gingival tissue	6.67E-02	7.05E-02	3.26E-01
Batten disease	5C56.1	Whole blood	4.63E-01	1.04E-01	1.18E+00
Behcet's disease	4A62	Peripheral blood	5.19E-01	3.03E-02	1.55E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.72E-01	4.22E-03	2.28E-02
Bladder cancer	2C94	Bladder tissue	1.16E-04	9.93E-01	3.24E+00
Breast cancer	2C60-2C6Z	Breast tissue	6.20E-04	-8.16E-02	-2.36E-01
Cardioembolic stroke	8B11.20	Whole blood	5.35E-04	1.19E-01	8.43E-01
Cervical cancer	2C77	Cervical tissue	5.96E-01	-6.85E-02	-5.13E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.09E-01	-7.93E-03	-2.47E-02
Chronic hepatitis C	1E51.1	Whole blood	3.22E-01	4.70E-02	2.89E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	1.13E-01	9.26E-02	3.35E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	3.23E-03	9.85E-02	4.65E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	8.21E-01	-4.09E-02	-2.44E-01
Colon cancer	2B90	Colon tissue	1.42E-05	-1.70E-01	-5.00E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	2.32E-01	-9.67E-02	-1.48E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.13E-01	1.87E-02	1.17E-01
Endometriosis	GA10	Endometrium tissue	3.96E-01	1.09E-01	4.36E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	4.80E-01	-4.19E-02	-2.00E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.68E-05	-2.62E-01	-8.54E-01
Gastric cancer	2B72	Gastric tissue	1.68E-01	-4.59E-01	-1.90E+00
Glioblastopma	2A00.00	Nervous tissue	3.05E-02	-7.87E-02	-2.57E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	3.39E-01	-6.05E-02	-7.70E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.10E-04	-5.78E-01	-2.26E+00
Head and neck cancer	2D42	Head and neck tissue	8.59E-02	2.61E-02	1.07E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	4.84E-01	-2.81E-02	-2.35E-01
Huntington's disease	8A01.10	Whole blood	1.99E-01	3.24E-02	4.95E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.88E-01	5.58E-02	4.07E-01
Immunodeficiency	4A00-4A20	Peripheral blood	6.71E-01	2.24E-02	2.37E-01
Influenza	1E30	Whole blood	7.30E-01	-3.61E-02	-1.33E-01
Interstitial cystitis	GC00.3	Bladder tissue	1.99E-01	6.97E-02	6.70E-01
Intracranial aneurysm	8B01.0	Intracranial artery	4.12E-01	-9.52E-03	-2.82E-02
Irritable bowel syndrome	DD91.0	Rectal colon tissue	6.60E-01	4.21E-02	1.49E-01
Ischemic stroke	8B11	Peripheral blood	3.79E-01	6.16E-02	4.16E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	8.65E-01	1.45E-04	7.25E-04
Lateral sclerosis	8B60.4	Skin	9.66E-01	9.96E-02	4.61E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	6.74E-01	5.68E-02	2.03E-01
Liver cancer	2C12.0	Liver tissue	4.09E-01	-3.11E-01	-2.86E-01
Liver failure	DB99.7-DB99.8	Liver tissue	4.80E-02	-4.85E-01	-1.23E+00
Lung cancer	2C25	Lung tissue	2.80E-05	-7.18E-02	-3.15E-01
Lupus erythematosus	4A40	Whole blood	2.07E-02	-1.65E-01	-2.80E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	2.63E-01	5.55E-02	3.10E-01
Major depressive disorder	6A70-6A7Z	Whole blood	1.95E-01	-2.38E-02	-1.00E-01
Melanoma	2C30	Skin	1.83E-04	-9.65E-01	-7.22E-01
Multiple myeloma	2A83.1	Peripheral blood	8.43E-01	-5.29E-02	-2.05E-01
Multiple myeloma	2A83.1	Bone marrow	3.85E-04	-6.34E-01	-2.09E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.86E-01	-6.25E-02	-2.03E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	8.33E-02	4.21E-02	1.40E-01
Myelofibrosis	2A20.2	Whole blood	6.96E-03	2.22E-01	1.16E+00
Myocardial infarction	BA41-BA50	Peripheral blood	3.23E-01	1.72E-01	2.97E-01
Myopathy	8C70.6	Muscle tissue	1.04E-01	-1.82E-01	-7.56E-01
Neonatal sepsis	KA60	Whole blood	6.65E-04	-2.10E-01	-6.99E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.71E-02	-4.80E-01	-9.42E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	3.11E-02	8.57E-01	1.37E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	7.70E-01	-1.07E-02	-5.99E-02
Olive pollen allergy	CA08.00	Peripheral blood	4.59E-01	1.11E-01	7.95E-01
Oral cancer	2B6E	Oral tissue	5.79E-06	-5.16E-01	-1.27E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	8.07E-02	-1.97E-01	-8.47E-01
Osteoporosis	FB83.1	Bone marrow	3.22E-01	2.08E-01	8.50E-01
Ovarian cancer	2C73	Ovarian tissue	7.09E-01	-8.57E-02	-2.08E-01
Pancreatic cancer	2C10	Pancreas	1.26E-02	-2.57E-01	-6.57E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	3.43E-01	-6.15E-02	-2.78E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	4.62E-01	3.67E-02	2.45E-01
Pituitary cancer	2D12	Pituitary tissue	1.06E-01	1.40E-01	4.17E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.09E-02	2.43E-01	1.27E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.45E-01	-3.38E-02	-2.01E-01
Polycythemia vera	2A20.4	Whole blood	1.23E-01	5.29E-02	2.87E-01
Pompe disease	5C51.3	Biceps muscle	4.15E-01	-6.44E-02	-3.64E-01
Preterm birth	KA21.4Z	Myometrium	7.05E-01	1.97E-01	6.27E-01
Prostate cancer	2C82	Prostate	1.48E-03	-5.04E-01	-9.63E-01
Psoriasis	EA90	Skin	3.41E-08	-2.96E-01	-6.73E-01
Rectal cancer	2B92	Rectal colon tissue	5.13E-01	-8.51E-02	-6.01E-01
Renal cancer	2C90-2C91	Kidney	2.95E-02	-1.08E+00	-1.45E+00
Retinoblastoma	2D02.2	Uvea	9.68E-06	-3.80E-01	-2.61E+00
Rheumatoid arthritis	FA20	Synovial tissue	9.32E-01	9.89E-03	2.70E-02
Rhinovirus infection	CA42.1	Nasal epithelium tissue	8.33E-01	-5.39E-03	-4.31E-02
Schizophrenia	6A20	Prefrontal cortex	5.41E-01	3.84E-03	1.24E-02
Schizophrenia	6A20	Superior temporal cortex	8.25E-01	-2.30E-02	-1.64E-01
Scleroderma	4A42.Z	Whole blood	4.07E-01	5.58E-02	3.88E-01
Seizure	8A60-8A6Z	Whole blood	3.60E-01	-7.44E-02	-3.01E-01
Sensitive skin	EK0Z	Skin	7.61E-01	-2.53E-01	-6.89E-01
Sepsis with septic shock	1G41	Whole blood	4.34E-01	-1.16E-02	-3.65E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	9.58E-01	1.34E-01	3.17E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.74E-01	1.01E-01	5.15E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	3.86E-01	-1.86E-02	-2.72E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.53E-02	-3.01E-01	-2.03E+00
Skin cancer	2C30-2C3Z	Skin	1.10E-08	-3.11E-01	-5.06E-01
Thrombocythemia	3B63	Whole blood	2.70E-01	-6.46E-03	-3.44E-02
Thrombocytopenia	3B64	Whole blood	7.24E-01	-1.75E-02	-6.42E-02
Thyroid cancer	2D10	Thyroid	2.82E-01	-3.73E-02	-1.78E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.43E-05	-1.87E-01	-1.35E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.37E-01	3.33E-02	1.73E-01
Type 2 diabetes	5A11	Liver tissue	1.58E-01	2.22E-01	7.47E-01
Ureter cancer	2C92	Urothelium	9.20E-01	-2.08E-03	-9.92E-03
Uterine cancer	2C78	Endometrium tissue	9.88E-01	1.39E-02	4.64E-02
Vitiligo	ED63.0	Skin	4.70E-01	-2.30E-02	-2.88E-02