Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE9RA0I)

• DME Name: Beta-glucuronidase (uidA) DME Info
• Gene Name: uidA

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Conjugated Estrogens	DMLT0E1	Dyspareunia	GA12	Approved	[1]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[2]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[3]
Ketoprofen glucuronide	DMX2FL3	N. A.	N. A.	Investigative	[4]
SN-38G	DM2UVNB	N. A.	N. A.	Investigative	[5]

References

• [1] Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
• [2] Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
• [3] Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.
• [4] Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35.
• [5] Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep. 2008 Oct;20(4):727-30.