Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DED2FW3)

• DME Name: Aldo-keto reductase 1A1 (AKR1A1) DME Info
• Gene Name: AKR1A1

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
NADH	DM5NM6E	Parkinson disease	8A00.0	Approved	[3]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3-dihydroxypropanal	DMOWNB4	Discovery agent	N.A.	Investigative	[4]
BRN-0471734	DMZMWVX	N. A.	N. A.	Investigative	[4]
D-glucuronate	DM1YBTC	N. A.	N. A.	Investigative	[4]
Nitrobenzaldehyde	DM4UHB5	N. A.	N. A.	Investigative	[4]

References

• [1] Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20.
• [2] Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
• [3] Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12.
• [4] The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80.