Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT056SO)

• DTT Name: Stress-activated protein kinase JNK3 (JNK3) DTT Info
• Gene Name: MAPK10

Molecule-Related Drug & Molecule List

17 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[1]
7-azaindole derivative 2	DMZRM2Q	N. A.	N. A.	Patented	[1]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[1]
7-azaindole derivative 4	DMW3EMH	N. A.	N. A.	Patented	[1]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[1]
7-azaindole derivative 6	DM8X5GP	N. A.	N. A.	Patented	[1]
7-azaindole derivative 7	DMB1WQZ	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-J5	DMU75ZX	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-P4	DMVF1D6	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-P5	DM6FCS9	N. A.	N. A.	Patented	[1]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[1]

12 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	DMDN12L	Discovery agent	N.A.	Investigative	[2]
9-(4-Hydroxyphenyl)-2,7-Phenanthroline	DMOL01E	Discovery agent	N.A.	Investigative	[2]
AC1LG8KT	DMFKV97	Discovery agent	N.A.	Investigative	[3]
Aminopyridine deriv. 2	DM94KQP	Discovery agent	N.A.	Investigative	[4]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[5]
AS-601245	DMQ95EB	Discovery agent	N.A.	Investigative	[6]
ELN-864709	DM2DERW	Central nervous system injury	KA40	Investigative	[3]
JNK-IN-8	DMLWYJB	Discovery agent	N.A.	Investigative	[7]
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	DMY1FMG	Discovery agent	N.A.	Investigative	[4]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide	DMUFVM6	Discovery agent	N.A.	Investigative	[4]
NSC-656158	DM52NOI	Discovery agent	N.A.	Investigative	[8]
Phenyl-(3-phenyl-1H-indazol-6-yl)-amine	DMDCTNU	Discovery agent	N.A.	Investigative	[9]

References

• [1] c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1498).
• [4] Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [6] A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
• [7] Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54.
• [8] Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumo... J Med Chem. 2010 Feb 25;53(4):1616-26.
• [9] Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9.