General Information of DTT (ID: TT0FYAN)

DTT Name Free fatty acid receptor 2 (FFAR2) DTT Info
Gene Name FFAR2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLPG0974 DMXO4T8 Abortion JA00 Phase 2 [1]
HL-018 DMT3HKZ Diabetic complication 5A2Y Phase 1 [2]
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8 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(S)-4-CMTB DMI12X9 Discovery agent N.A. Investigative [3]
1-methylcyclopropanecarboxylic acid DMDIH07 Discovery agent N.A. Investigative [4]
AMG7703 DMJ6L9U Discovery agent N.A. Investigative [5]
CATPB DMF7TBW Discovery agent N.A. Investigative [3]
isobutyric acid DMX4VY9 Discovery agent N.A. Investigative [6]
pentanoic acid DM56RAX Discovery agent N.A. Investigative [7]
PMID23589301C1 DMB7TE6 Discovery agent N.A. Investigative [8]
trans-2-methylcrotonic acid DMHJM0B Discovery agent N.A. Investigative [4]
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⏷ Show the Full List of 8 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 226).
3 Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209.
4 Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40.
5 Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011 Jul;80(1):163-73.
6 Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003 Jul 11;278(28):25481-9.
7 The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003 Mar 28;278(13):11312-9.
8 Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem. 2013 Jun 14;288(24):17296-312.