Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT0JLSD)

• DTT Name: Multidrug resistance protein (MDR) DTT Info
• Gene Name: MDR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzquinamide	DMU4D5Y	Nausea	MD90	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]
MM36	DM6VPIO	Atopic dermatitis	EA80	Phase 2	[2]
Ortataxel	DM1EK5D	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valspodar	DMXRU9M	Acute myeloid leukaemia	2A60	Discontinued in Phase 3	[4]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chemosensitizers	DMYSG9J	Discovery agent	N.A.	Investigative	[5]
KP772	DMUZSJ2	Discovery agent	N.A.	Investigative	[2]
WK-X-34	DMX0ZBC	Discovery agent	N.A.	Investigative	[2]

References

• [1] Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65.
• [2] Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74.
• [3] Clinical pipeline report, company report or official report of Spectrum Phamaceuticals (2009).
• [4] Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15. Jpn J Cancer Res. 2001 Oct;92(10):1116-26.
• [5] P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Curr Drug Targets. 2000 Jul;1(1):85-99.