General Information of DTT (ID: TT0MI3F)

DTT Name 5-HT 1F receptor (HTR1F) DTT Info
Gene Name HTR1F

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lasmiditan DMXLVDT Migraine 8A80 Approved [1]
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [2]
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1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY-334370 DM43O9N Migraine 8A80 Phase 2 [3]
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11 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
1-naphthylpiperazine DM6BIWK Discovery agent N.A. Investigative [2]
2-methyl-5-HT DM1S5CB N. A. N. A. Investigative [4]
5-BODMT DM7BWG5 Discovery agent N.A. Investigative [5]
5-CT DM260KD Discovery agent N.A. Investigative [2]
alpha-methyl-5-HT DMCAYXF Discovery agent N.A. Investigative [4]
BRL-15572 DMM61Y2 Discovery agent N.A. Investigative [6]
dipropyl-5-CT DM9VKXC Discovery agent N.A. Investigative [4]
LY344864 DM8LSQP Discovery agent N.A. Investigative [7]
TFMPP DMAC8TP Discovery agent N.A. Investigative [4]
WAY-466 DMMOH51 Discovery agent N.A. Investigative [8]
[125I]LSD DMP69QG Discovery agent N.A. Investigative [9]
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⏷ Show the Full List of 11 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76.
3 Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4.
4 Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
5 Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.
6 SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
7 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.
8 Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6.
9 Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4.