Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT0SFXH)

• DTT Name: Fungal 1,3-beta-glucan synthase (Fung GSC2) DTT Info
• Gene Name: Fung GSC2

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anidulafungin	DM8QM5U	Aspergillosis	1F20	Approved	[1]
Caspofungin	DMGQIPT	Candidiasis	1F23	Approved	[2]
Ibrexafungerp	DMK1IPV	Vulvovaginal Candidiasis	1F23.10	Approved	[3]
Micafungin	DM6Y3AN	Aspergillosis	1F20	Approved	[4]
Rezafungin	DMQ4CSX	Candidiasis	1F23	Approved	[5]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-733560	DMYZPJU	Aspergillosis	1F20	Terminated	[6]

References

• [1] 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72.
• [4] An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicrob Chemother. 2014 Apr;69(4):1065-74.
• [5] Antifungal drugs: What brings the future?. Med Mycol. 2019 Jun 1;57(Supplement_3):S328-S343.
• [6] Discovery of Novel Antifungal (1,3)--d-Glucan Synthase Inhibitors