Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT12ABZ)

• DTT Name: Arachidonate 12-lipoxygenase (12-LOX) DTT Info
• Gene Name: ALOX12

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[1]

19 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol	DMLDQWT	Discovery agent	N.A.	Investigative	[2]
(+)-(5S,8S,10S)-20-methoxypuupehenol	DMU7BJA	Discovery agent	N.A.	Investigative	[2]
(+)-(5S,8S,9R,10S)-20-methoxypuupehenone	DMD4YPO	Discovery agent	N.A.	Investigative	[2]
(-)-7-N-methyldibromophakellin	DM396OK	Discovery agent	N.A.	Investigative	[3]
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol	DMK4LTB	Discovery agent	N.A.	Investigative	[4]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol	DMO34LJ	Discovery agent	N.A.	Investigative	[4]
CHLOROPUUPEHENONE	DM8B0VZ	Discovery agent	N.A.	Investigative	[2]
Dimethylnordihydroguarierate acid	DMG3WTE	Discovery agent	N.A.	Investigative	[2]
DYSIDENIN	DMIZQTX	Discovery agent	N.A.	Investigative	[1]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[5]
Jaspic acid	DMOF0TB	Discovery agent	N.A.	Investigative	[2]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[1]
NEODYSIDENIN	DM5EWIK	Discovery agent	N.A.	Investigative	[1]
NSC-125034	DM3NQDW	Discovery agent	N.A.	Investigative	[1]
NSC-172033	DM9QW8N	Discovery agent	N.A.	Investigative	[1]
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[1]
Polybrominated diphenyl ether derivative	DMG7K84	Discovery agent	N.A.	Investigative	[4]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[5]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[2]

References

• [1] Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
• [2] Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
• [3] An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. J Nat Prod. 2004 Aug;67(8):1256-61.
• [4] Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
• [5] Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.