Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT1RWL7)

• DTT Name: Hepatitis A virus cellular receptor 2 (TIM3) DTT Info
• Gene Name: Hepatitis A virus HAVCR2

Molecule-Related Drug & Molecule List

10 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MBG453	DMBPY9Z	Myelodysplastic syndrome	2A37	Phase 3	[1]
AZD7789	DMOIHWI	Hodgkin lymphoma	2B30	Phase 2	[2]
GSK4069889	DMV6SNU	Non-small-cell lung cancer	2C25	Phase 2	[3]
RO7121661	DM8A120	Esophageal squamous cell carcinoma	2E60.1	Phase 2	[4]
TB006	DMKN524	Alzheimer disease	8A20	Phase 2	[5]
BGB-A425	DMI42Q0	Non-small-cell lung cancer	2C25	Phase 1/2	[6]
INCAGN2390	DM5SO1T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
LY3321367	DMD51GC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
LY3415244	DM5QO1A	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
Sym023	DMV3L62	Lymphoma	2A80-2A86	Phase 1	[9]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of AstraZeneca
• [3] Clinical pipeline report, company report or official report of GlaxoSmithKline.
• [4] Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608.
• [5] Clinical pipeline report, company report or official report of TrueBinding
• [6] Clinical pipeline report, company report or official report of BeiGene.
• [7] Clinical pipeline report, company report or official report of Agenus.
• [8] Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2773-2781.
• [9] Clinical pipeline report, company report or official report of Symphogen.