Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT1TYN7)

DTT Name	Nuclear receptor ROR-alpha (RORA) DTT Info
Gene Name	RORA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9598431, 3	DMRC4O7	N. A.	N. A.	Patented	[1]
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2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SR1078	DM7MDZE	Liver cancer	2C12	Preclinical	[2]
SR3335	DM96IUW	Type-2 diabetes	5A11	Preclinical	[3]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
7-hydroxycholesterol	DMZXMB7	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Compounds useful for inhibiting ROR-gamma-t. US9598431.
2	Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.
3	Identification of SR3335 (ML-176): a synthetic RORalpha selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22.
4	Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem. 2003 Dec 1;323(1):139-49.