Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2EDHU)

• DTT Name: Insulin-degrading enzyme (IDE) DTT Info
• Gene Name: IDE

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bacitracin	DM5OHYE	Blepharoconjunctivitis		Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRO-001	DM5ZTE4	Retinitis pigmentosa	9B70	Phase 2	[2]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GNF-PF-4478	DMCDU8K	Discovery agent	N.A.	Investigative	[3]
NTE-1	DMFIE0U	Discovery agent	N.A.	Investigative	[4]
NTE-2	DM4DB0W	Discovery agent	N.A.	Investigative	[4]
quinoline 2	DM1QIPZ	Discovery agent	N.A.	Investigative	[4]

References

• [1] Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci. 2004 Oct 27;24(43):9632-7.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2371).
• [3] In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
• [4] Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59.