Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2GPK3)

• DTT Name: DNA topoisomerase (TOP) DTT Info
• Gene Name: TOP

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[1]
Icofungipen	DMTXNZK	Fungal infection	1F29-1F2F	Phase 2	[2]

14 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one	DMECHD0	Discovery agent	N.A.	Investigative	[3]
3-(9-Acridinylamino)-5-(hydroxymethyl)aniline (AHMA)	DMDIQ7H	Discovery agent	N.A.	Investigative	[2]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione	DMTPRIW	Discovery agent	N.A.	Investigative	[3]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione	DMMFWYX	Discovery agent	N.A.	Investigative	[4]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione	DMKUHN9	Discovery agent	N.A.	Investigative	[4]
6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione	DMISV5A	Discovery agent	N.A.	Investigative	[4]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione	DMSH107	Discovery agent	N.A.	Investigative	[4]
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione	DMM2TFX	Discovery agent	N.A.	Investigative	[4]
6-Benzylamino-1H-pyrimidine-2,4-dione	DM8FUZL	Discovery agent	N.A.	Investigative	[3]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione	DMGJYWF	Discovery agent	N.A.	Investigative	[3]
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione	DM8FTNC	Discovery agent	N.A.	Investigative	[3]
6-p-Tolylamino-1H-pyrimidine-2,4-dione	DMIAQUC	Discovery agent	N.A.	Investigative	[4]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine	DMNGSQK	Discovery agent	N.A.	Investigative	[3]
TOPOSTATIN	DMNZQO9	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
• [3] Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.
• [4] Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.
• [5] Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.