Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT3VZ24)

DTT Name	NIMA-related kinase 2 (NEK2) DTT Info
Gene Name	NEK2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK579289A	DMJXHU8	Discovery agent	N.A.	Investigative	[1]
PMID20936789C31	DMUGWO6	Discovery agent	N.A.	Investigative	[2]
PMID21627121C2	DMQHAIK	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1694-7.
2	Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010 Nov 11;53(21):7682-98.
3	Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23;54(12):4133-46.