Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT3ZS42)

• DTT Name: Phosphodiesterase 1B (PDE1B) DTT Info
• Gene Name: PDE1B

Molecule-Related Drug & Molecule List

11 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AC1LDDOQ	DMKTMCH	N. A.	N. A.	Patented	[1]
AC1MOZOL	DM6293C	N. A.	N. A.	Patented	[2]
US10034861, Example 1	DMLJV01	N. A.	N. A.	Patented	[3]
US10034861, Example 164	DM27SFD	N. A.	N. A.	Patented	[3]
US10034861, Example 165	DMD8FS5	N. A.	N. A.	Patented	[3]
US10092575, Example 101	DMU8CAD	N. A.	N. A.	Patented	[1]
US10092575, Example 141	DMT47DF	N. A.	N. A.	Patented	[4]
US10092575, Example 158	DM7MNE2	N. A.	N. A.	Patented	[1]
US9073936, 1	DMZD1L5	N. A.	N. A.	Patented	[5]
US9073936, 2	DMZH3MX	N. A.	N. A.	Patented	[5]
US9073936, 3	DMS9W6O	N. A.	N. A.	Patented	[5]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IC-041	DMRF5LU	Cognitive impairment	6D71	Investigative	[6]
SCH51866	DMCWSJP	Discovery agent	N.A.	Investigative	[7]

References

• [1] Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds. US10092575.
• [2] Inhibitors of phosphodiesterase 11 (PDE11). US9173884.
• [3] 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors. US10034861.
• [4] Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones. US10105367.
• [5] Organic compounds. US9598426.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1295).
• [7] Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9.