Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT4H0V2)

• DTT Name: Dipeptidyl peptidase I (CTSC) DTT Info
• Gene Name: CTSC

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1291583	DMOZGBQ	Non-cystic fibrosis bronchiectasis	CA24	Phase 2	[1]
GSK2793660	DMSGNVK	Bronchiectasis	CA24	Phase 1	[2]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide	DMN1G8L	Discovery agent	N.A.	Investigative	[3]
GNF-PF-5434	DMP9AIH	Discovery agent	N.A.	Investigative	[4]
PMID3941405C3d	DM6ZOW4	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of boehringer-ingelheim
• [2] ClinicalTrials.gov (NCT02058407) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects. U.S. National Institutes of Health.
• [3] Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7.
• [4] Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70.
• [5] Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104-11.