Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT54ERL)

DTT Name	Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DTT Info
UniProt ID	SCN8A_HUMAN
Gene Name	SCN8A

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRAX-330	DMHIS3M	Epilepsy	8A60-8A68	Phase 1	[1]
XEN901	DMRP9YF	Epilepsy	8A60-8A68	Phase 1	[2]
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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4,9-anhydro-tetrodotoxin	DMEKI1B	Discovery agent	N.A.	Investigative	[3]
Batrachotoxin	DMYH9SU	Discovery agent	N.A.	Investigative	[4]
Veratridine	DMUF8JZ	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
3	The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel. Am J Physiol Cell Physiol. 2007 Aug;293(2):C783-9.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583).