Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT57MT2)

• DTT Name: PKC-epsilon messenger RNA (PRKCE mRNA) DTT Info
• UniProt ID: KPCE_HUMAN
• Gene Name: PRKCE

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[1]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
8-Octyl-benzolactam-V9	DM4Z15M	Discovery agent	N.A.	Investigative	[2]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[3]
Chelerythrine	DMCP1G9	Discovery agent	N.A.	Investigative	[4]
ISIS 7942	DMN0A1R	Discovery agent	N.A.	Investigative	[5]
ISIS 7948	DMYZE8R	Discovery agent	N.A.	Investigative	[5]
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]

References

• [1] Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
• [2] Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
• [3] Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.
• [4] A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
• [5] US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
• [6] A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
• [7] Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.