Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5FLYB)

• DTT Name: Staphylococcus Alpha-hemolysin (Stap-coc hly) DTT Info
• Gene Name: Stap-coc hly

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AR-301	DM2YQK8	Ventilator-associated pneumonia	PK81.0	Phase 3	[1]
Cyrtominetin	DM0JA9N	Phlegmy cough	SA80-SA8Z	Phase 3	[2]
MEDI4893	DMXB4NL	Ventilator-associated pneumonia	PK81.0	Phase 2b	[3]
ASN100	DMWPGLS	Hospital-acquired pneumonia	CA40.Z	Phase 2	[4]

References

• [1] Clinical pipeline report, company report or official report of Aridis Pharmaceuticals.
• [2] Molecular insight into the inhibition mechanism of cyrtominetin to alpha-hemolysin by molecular dynamics simulation. Eur J Med Chem. 2013 Apr;62:320-8.
• [3] Mechanisms of neutralization of a human anti-alpha-toxin antibody. J Biol Chem. 2014 Oct 24;289(43):29874-80.
• [4] Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015 Nov;14(11):737-8.