General Information of DTT (ID: TT5MLZR)

DTT Name Cryptochrome circadian clock 1 (CRY1) DTT Info
Gene Name CRY1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
4 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Ethoxypropanoic acid DMAM4FE Breast cancer 2C60-2C65 Preclinical [1]
KL001 DMHX1LA Glioblastoma of brain 2A00.00 Preclinical [2]
SHP656 DM8DYJQ Glioblastoma of brain 2A00.00 Preclinical [3]
TH301 DM4BDGW Glioblastoma of brain 2A00.00 Preclinical [3]
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1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
KL044 DMG3FDE Discovery agent N.A. Investigative [4]
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Molecule Interaction Atlas

References

1 The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.
2 Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
3 Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
4 Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.