Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5MLZR)

DTT Name	Cryptochrome circadian clock 1 (CRY1) DTT Info
Gene Name	CRY1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

4 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Ethoxypropanoic acid	DMAM4FE	Breast cancer	2C60-2C65	Preclinical	[1]
KL001	DMHX1LA	Glioblastoma of brain	2A00.00	Preclinical	[2]
SHP656	DM8DYJQ	Glioblastoma of brain	2A00.00	Preclinical	[3]
TH301	DM4BDGW	Glioblastoma of brain	2A00.00	Preclinical	[3]
------------------------------------------------------------------------------------

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KL044	DMG3FDE	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.
2	Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
3	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
4	Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.