Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5OU0D)

• DTT Name: PRKR-like endoplasmic reticulum kinase (PERK) DTT Info
• Gene Name: EIF2AK3

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HC-5404	DMKFZW5	Breast cancer	2C60-2C65	Phase 1	[1]

17 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indoline derivative 10	DMTPGRO	N. A.	N. A.	Patented	[2]
Indoline derivative 11	DM6JR3X	N. A.	N. A.	Patented	[2]
Indoline derivative 2	DMASXR5	N. A.	N. A.	Patented	[2]
Indoline derivative 3	DM20YBJ	N. A.	N. A.	Patented	[2]
Indoline derivative 6	DMU5KWC	N. A.	N. A.	Patented	[2]
Indoline derivative 7	DMXS46Y	N. A.	N. A.	Patented	[2]
Indoline derivative 8	DMS8KMB	N. A.	N. A.	Patented	[2]
Indoline derivative 9	DMCORT3	N. A.	N. A.	Patented	[2]
Phenylpyrrolidinone derivative 1	DMPAI5C	N. A.	N. A.	Patented	[2]
Phenylpyrrolidinone derivative 2	DMF3NCO	N. A.	N. A.	Patented	[2]
Phenylpyrrolidinone derivative 3	DMPZKQN	N. A.	N. A.	Patented	[2]
Phenylpyrrolidinone derivative 4	DMSX47Q	N. A.	N. A.	Patented	[2]
Phenylpyrrolidinone derivative 5	DMZSTLH	N. A.	N. A.	Patented	[2]
Tricyclic isoxazoloquinazoline derivative 1	DM6QSND	N. A.	N. A.	Patented	[2]
Tricyclic isoxazoloquinazoline derivative 2	DMH4TY1	N. A.	N. A.	Patented	[2]
Tricyclic isoxazoloquinazoline derivative 3	DML2PWF	N. A.	N. A.	Patented	[2]
Tricyclic isoxazoloquinazoline derivative 4	DM8VIM4	N. A.	N. A.	Patented	[2]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2606414	DMLASOF	Discovery agent	N.A.	Investigative	[3]

References

• [1] Clinical pipeline report, company report or official report of HiberCell
• [2] Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48.
• [3] Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.