Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5QA2I)

• DTT Name: Plasminogen activator inhibitor (PAI) DTT Info
• Gene Name: SERPINE1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aleplasinin	DMYTIP4	Alzheimer disease	8A20	Phase 1	[1]

4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BX-044	DM0P8CE	Thrombosis	DB61-GB90	Terminated	[2]
T-686	DMOGQ2L	Arteriosclerosis	BD40	Terminated	[3]
XR-1853	DMFHR2O	Thrombosis	DB61-GB90	Terminated	[4]
XR-5082	DMEVSZO	Thrombosis	DB61-GB90	Terminated	[5]

References

• [1] CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders.
• [2] Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res. 2005;115(4):341-50.
• [3] T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6.
• [4] Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43.
• [5] Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15.