Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5U49F)

• DTT Name: PRKACA messenger RNA (PRKACA mRNA) DTT Info
• UniProt ID: KAPCA_HUMAN
• Gene Name: PRKACA

Molecule-Related Drug & Molecule List

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGGGWZCOULSEER-PYUWXLGESA-N	DM2L83Y	N. A.	N. A.	Patented	[1]
VFEDEOUBYBLDKN-AAFJCEBUSA-N	DMH9ION	N. A.	N. A.	Patented	[1]
XHPNYYOUZWOWNT-PYUWXLGESA-N	DM5Q93Y	N. A.	N. A.	Patented	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[2]

28 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[3]
H-89	DM4RVGO	Discovery agent	N.A.	Investigative	[4]
ISIS 102450	DML40N3	Discovery agent	N.A.	Investigative	[5]
ISIS 102454	DMNSEH1	Discovery agent	N.A.	Investigative	[5]
ISIS 102458	DMBUTFN	Discovery agent	N.A.	Investigative	[5]
ISIS 102462	DMXNC0B	Discovery agent	N.A.	Investigative	[5]
ISIS 102466	DMAG8QO	Discovery agent	N.A.	Investigative	[5]
ISIS 102478	DMU70ND	Discovery agent	N.A.	Investigative	[5]
ISIS 102482	DMMBJWK	Discovery agent	N.A.	Investigative	[5]
ISIS 102486	DMTMBEX	Discovery agent	N.A.	Investigative	[5]
ISIS 102490	DMMWVCH	Discovery agent	N.A.	Investigative	[5]
ISIS 102558	DMYJO7T	Discovery agent	N.A.	Investigative	[5]
ISIS 102563	DMTHMF0	Discovery agent	N.A.	Investigative	[5]
ISIS 102584	DMEDFLA	Discovery agent	N.A.	Investigative	[5]
ISIS 102599	DM3RVUY	Discovery agent	N.A.	Investigative	[5]
ISIS 102604	DMZ6X9B	Discovery agent	N.A.	Investigative	[5]
ISIS 102609	DM60LT9	Discovery agent	N.A.	Investigative	[5]
ISIS 102614	DMEB36I	Discovery agent	N.A.	Investigative	[5]
ISIS 102619	DMXH9IT	Discovery agent	N.A.	Investigative	[5]
ISIS 102624	DMGO4TZ	Discovery agent	N.A.	Investigative	[5]
ISIS 102629	DMNSZPX	Discovery agent	N.A.	Investigative	[5]
ISIS 102633	DMWT7BK	Discovery agent	N.A.	Investigative	[5]
ISIS 102660	DM6KUV9	Discovery agent	N.A.	Investigative	[5]
ISIS 102664	DMKI6L5	Discovery agent	N.A.	Investigative	[5]
ISIS 102668	DMY87QX	Discovery agent	N.A.	Investigative	[5]
ISIS 102676	DMFP598	Discovery agent	N.A.	Investigative	[5]
NM-PP1	DMS8H5Q	Discovery agent	N.A.	Investigative	[6]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[7]

References

• [1] Purine derivatives. US8846696.
• [2] Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address
• [3] 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
• [4] Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 1990 Mar 25;265(9):5267-72.
• [5] US patent application no. 6,248,586, Antisense modulation of PKA catalytic subunit C-alpha expression.
• [6] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [7] Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3.