Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT69DB8)

• DTT Name: Beta-site APP-cleaving enzyme 2 (BACE2) DTT Info
• Gene Name: BACE2

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
example 98 (WO2011020806)	DM2N653	Focal segmental glomerulosclerosis	MF8Y	Clinical trial	[1]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2ewy	DMNOAJG	Discovery agent	N.A.	Investigative	[2]
example 2 (WO2013004676)	DMU25HZ	Discovery agent	N.A.	Investigative	[3]
example 20 (WO2010128058)	DMF9W41	Discovery agent	N.A.	Investigative	[4]
example 41 (WO2012028563)	DM2N9Y8	Discovery agent	N.A.	Investigative	[4]
example 92 (WO2012095521)	DMU42CR	Discovery agent	N.A.	Investigative	[4]
PMID21907142CJ	DMST0IN	Discovery agent	N.A.	Investigative	[5]

References

• [1] BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63.
• [2] Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61.
• [3] Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331).
• [5] Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77.